BET protein inhibitor JQ1 downregulates chromatin accessibility and suppresses metastasis of gastric cancer via inactivating RUNX2/NID1 signaling

Chromatin accessibility is critical for tumor development, whose mechanisms remain unclear. As a crucial regulator for chromatin remodeling, BRD4 promotes tumor progression by regulating multiple genes. As a small-molecule inhibitor of BRD4, JQ1 has potent chemotherapeutic activity against various h...

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Detalles Bibliográficos
Autores principales: Zhou, Siqi, Zhang, Shu, Wang, Lei, Huang, Shuling, Yuan, Yue, Yang, Jie, Wang, Hui, Li, Xihan, Wang, Pin, Zhou, Lin, Yang, Jun, Xu, Yuemei, Gao, Huan, Zhang, Yixuan, Lv, Ying, Zou, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064486/
https://www.ncbi.nlm.nih.gov/pubmed/32157097
http://dx.doi.org/10.1038/s41389-020-0218-z

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