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Genetic epidemiology of the Alpine ibex reservoir of persistent and virulent brucellosis outbreak

While it is now broadly accepted that inter-individual variation in the outcomes of host–pathogen interactions is at least partially genetically controlled, host immunogenetic characteristics are rarely investigated in wildlife epidemiological studies. Furthermore, most immunogenetic studies in the...

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Autores principales: Quéméré, Erwan, Rossi, Sophie, Petit, Elodie, Marchand, Pascal, Merlet, Joël, Game, Yvette, Galan, Maxime, Gilot-Fromont, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064506/
https://www.ncbi.nlm.nih.gov/pubmed/32157133
http://dx.doi.org/10.1038/s41598-020-61299-2
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author Quéméré, Erwan
Rossi, Sophie
Petit, Elodie
Marchand, Pascal
Merlet, Joël
Game, Yvette
Galan, Maxime
Gilot-Fromont, Emmanuelle
author_facet Quéméré, Erwan
Rossi, Sophie
Petit, Elodie
Marchand, Pascal
Merlet, Joël
Game, Yvette
Galan, Maxime
Gilot-Fromont, Emmanuelle
author_sort Quéméré, Erwan
collection PubMed
description While it is now broadly accepted that inter-individual variation in the outcomes of host–pathogen interactions is at least partially genetically controlled, host immunogenetic characteristics are rarely investigated in wildlife epidemiological studies. Furthermore, most immunogenetic studies in the wild focused solely on the major histocompatibility complex (MHC) diversity despite it accounts for only a fraction of the genetic variation in pathogen resistance. Here, we investigated immunogenetic diversity of the Alpine ibex (Capra ibex) population of the Bargy massif, reservoir of a virulent outbreak of brucellosis. We analysed the polymorphism and associations with disease resistance of the MHC Class II Drb gene and several non-MHC genes (Toll-like receptor genes, Slc11A1) involved in the innate immune response to Brucella in domestic ungulates. We found a very low neutral genetic diversity and a unique MHC Drb haplotype in this population founded few decades ago from a small number of individuals. By contrast, other immunity-related genes have maintained polymorphism and some showed significant associations with the brucellosis infection status hence suggesting a predominant role of pathogen-mediated selection in their recent evolutionary trajectory. Our results highlight the need to monitor immunogenetic variation in wildlife epidemiological studies and to look beyond the MHC.
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spelling pubmed-70645062020-03-18 Genetic epidemiology of the Alpine ibex reservoir of persistent and virulent brucellosis outbreak Quéméré, Erwan Rossi, Sophie Petit, Elodie Marchand, Pascal Merlet, Joël Game, Yvette Galan, Maxime Gilot-Fromont, Emmanuelle Sci Rep Article While it is now broadly accepted that inter-individual variation in the outcomes of host–pathogen interactions is at least partially genetically controlled, host immunogenetic characteristics are rarely investigated in wildlife epidemiological studies. Furthermore, most immunogenetic studies in the wild focused solely on the major histocompatibility complex (MHC) diversity despite it accounts for only a fraction of the genetic variation in pathogen resistance. Here, we investigated immunogenetic diversity of the Alpine ibex (Capra ibex) population of the Bargy massif, reservoir of a virulent outbreak of brucellosis. We analysed the polymorphism and associations with disease resistance of the MHC Class II Drb gene and several non-MHC genes (Toll-like receptor genes, Slc11A1) involved in the innate immune response to Brucella in domestic ungulates. We found a very low neutral genetic diversity and a unique MHC Drb haplotype in this population founded few decades ago from a small number of individuals. By contrast, other immunity-related genes have maintained polymorphism and some showed significant associations with the brucellosis infection status hence suggesting a predominant role of pathogen-mediated selection in their recent evolutionary trajectory. Our results highlight the need to monitor immunogenetic variation in wildlife epidemiological studies and to look beyond the MHC. Nature Publishing Group UK 2020-03-10 /pmc/articles/PMC7064506/ /pubmed/32157133 http://dx.doi.org/10.1038/s41598-020-61299-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Quéméré, Erwan
Rossi, Sophie
Petit, Elodie
Marchand, Pascal
Merlet, Joël
Game, Yvette
Galan, Maxime
Gilot-Fromont, Emmanuelle
Genetic epidemiology of the Alpine ibex reservoir of persistent and virulent brucellosis outbreak
title Genetic epidemiology of the Alpine ibex reservoir of persistent and virulent brucellosis outbreak
title_full Genetic epidemiology of the Alpine ibex reservoir of persistent and virulent brucellosis outbreak
title_fullStr Genetic epidemiology of the Alpine ibex reservoir of persistent and virulent brucellosis outbreak
title_full_unstemmed Genetic epidemiology of the Alpine ibex reservoir of persistent and virulent brucellosis outbreak
title_short Genetic epidemiology of the Alpine ibex reservoir of persistent and virulent brucellosis outbreak
title_sort genetic epidemiology of the alpine ibex reservoir of persistent and virulent brucellosis outbreak
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064506/
https://www.ncbi.nlm.nih.gov/pubmed/32157133
http://dx.doi.org/10.1038/s41598-020-61299-2
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