Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice

The DNA damage response after kidney injury induces cell cycle arrest in renal tubular epithelial cells, resulting in the secretion of pro-fibrotic cytokines, thereby promoting interstitial fibrosis in a paracrine manner. Phosphorylation of ataxia-telangiectasia mutated (ATM) is the initial step in...

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Detalles Bibliográficos
Autores principales: Uehara, Masahiro, Kusaba, Tetsuro, Ida, Tomoharu, Nakai, Kunihiro, Nakata, Tomohiro, Tomita, Aya, Watanabe-Uehara, Noriko, Ikeda, Kisho, Kitani, Takashi, Yamashita, Noriyuki, Kirita, Yuhei, Matoba, Satoaki, Humphreys, Benjamin D., Tamagaki, Keiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064514/
https://www.ncbi.nlm.nih.gov/pubmed/32157166
http://dx.doi.org/10.1038/s41598-020-61456-7

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