Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus

Type I interferon (IFN) drives pathology in systemic lupus erythematosus (SLE) and can be tracked via IFN-inducible transcripts in blood. Here, we examined whether measurement of circulating proteins, which enter the bloodstream from inflamed tissues, also offers insight into global IFN activity. Us...

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Detalles Bibliográficos
Autores principales: Smith, Michael A., Chiang, Chia-Chien, Zerrouki, Kamelia, Rahman, Saifur, White, Wendy I., Streicher, Katie, Rees, William A., Schiffenbauer, Adam, Rider, Lisa G., Miller, Frederick W., Manna, Zerai, Hasni, Sarfaraz, Kaplan, Mariana J., Siegel, Richard, Sinibaldi, Dominic, Sanjuan, Miguel A., Casey, Kerry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064569/
https://www.ncbi.nlm.nih.gov/pubmed/32157125
http://dx.doi.org/10.1038/s41598-020-60563-9

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