An APC Mutation in a Large Chinese Kindred With Familial Adenomatous Polyposis Was Identified Using Both Next Generation Sequencing and Simple STR Marker Haplotypes

BACKGROUND: Familial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized primarily by the development of numerous adenomatous polyps in the colon and a high risk for colorectal cancer. FAP is caused by germline mutations of the adenomatous polyposis coli (APC) gene. The proba...

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Detalles Bibliográficos
Autores principales: Zhan, Qitao, Wang, Liya, Xu, Xiangrong, Sun, Yan, Li, Lejun, Qi, Xuchen, Chen, Feng, Wei, Xiaoming, Raff, Michael L., Yu, Ping, Jin, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064715/
https://www.ncbi.nlm.nih.gov/pubmed/32194643
http://dx.doi.org/10.3389/fgene.2020.00191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064715/
https://www.ncbi.nlm.nih.gov/pubmed/32194643
http://dx.doi.org/10.3389/fgene.2020.00191

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