Merkel Cell Polyomavirus DNA Replication Induces Senescence in Human Dermal Fibroblasts in a Kap1/Trim28-Dependent Manner

Merkel cell polyomavirus (MCPyV) is the only polyomavirus known to be associated with tumorigenesis in humans. Similarly to other polyomaviruses, MCPyV expresses a large tumor antigen (LT-Ag) that, together with a small tumor antigen (sT-Ag), contributes to cellular transformation and that is of cri...

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Detalles Bibliográficos
Autores principales: Siebels, Svenja, Czech-Sioli, Manja, Spohn, Michael, Schmidt, Claudia, Theiss, Juliane, Indenbirken, Daniela, Günther, Thomas, Grundhoff, Adam, Fischer, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064754/
https://www.ncbi.nlm.nih.gov/pubmed/32156811
http://dx.doi.org/10.1128/mBio.00142-20

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