Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants

Each year, >180,000 infants become infected via mother-to-child transmission (MTCT) of HIV despite the availability of effective maternal antiretroviral treatments, underlining the need for a maternal HIV vaccine. We characterized 224 maternal HIV envelope (Env)-specific IgG monoclonal antibodies...

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Detalles Bibliográficos
Autores principales: Martinez, David R., Tu, Joshua J., Kumar, Amit, Mangold, Jesse F., Mangan, Riley J., Goswami, Ria, Giorgi, Elena E., Chen, Juilin, Mengual, Michael, Douglas, Ayooluwa O., Heimsath, Holly, Saunders, Kevin O., Nicely, Nathan I., Eudailey, Joshua, Hernandez, Giovanna, Morgan-Asiedu, Papa Kwadwo, Wiehe, Kevin, Haynes, Barton F., Moody, M. Anthony, LaBranche, Celia, Montefiori, David C., Gao, Feng, Permar, Sallie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064758/
https://www.ncbi.nlm.nih.gov/pubmed/32156815
http://dx.doi.org/10.1128/mBio.00176-20

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