Optimized Inhibitors of MDM2 via an Attempted Protein‐Templated Reductive Amination

Innovative and efficient hit‐identification techniques are required to accelerate drug discovery. Protein‐templated fragment ligations represent a promising strategy in early drug discovery, enabling the target to assemble and select its binders from a pool of building blocks. Development of new pro...

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Detalles Bibliográficos
Autores principales: van der Vlag, Ramon, Yagiz Unver, M., Felicetti, Tommaso, Twarda‐Clapa, Aleksandra, Kassim, Fatima, Ermis, Cagdas, Neochoritis, Constantinos G., Musielak, Bogdan, Labuzek, Beata, Dömling, Alexander, Holak, Tad A., Hirsch, Anna K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064911/
https://www.ncbi.nlm.nih.gov/pubmed/31774938
http://dx.doi.org/10.1002/cmdc.201900574

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