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Improving safety of the continual reassessment method via a modified allocation rule
This article proposes a novel criterion for the allocation of patients in phase I dose‐escalation clinical trials, aiming to find the maximum tolerated dose (MTD). Conventionally, using a model‐based approach, the next patient is allocated to the dose with the toxicity estimate closest (in terms of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064916/ https://www.ncbi.nlm.nih.gov/pubmed/31859399 http://dx.doi.org/10.1002/sim.8450 |