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Calcineurin inhibitors reduce NFAT‐dependent expression of antifungal pentraxin‐3 by human monocytes

Calcineurin (CN) inhibitors are effective clinical immunosuppressants but leave patients vulnerable to potentially fatal fungal infections. This study tested the hypothesis that CN inhibition interferes with antifungal immune defenses mediated by monocytes. We showed that NFAT is expressed by human...

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Detalles Bibliográficos
Autores principales:	Bendíčková, Kamila, Tidu, Federico, De Zuani, Marco, Kohoutková, Marcela Hortová, Andrejčinová, Ivana, Pompeiano, Antonio, Bělášková, Silvie, Forte, Giancarlo, Zelante, Teresa, Frič, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Host Defense & Pathophysiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064969/ https://www.ncbi.nlm.nih.gov/pubmed/30934147 http://dx.doi.org/10.1002/JLB.4VMA0318-138R

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