Regulatory T cells and co‐evolution of allele‐specific MHC recognition by the TCR

What is the evolutionary mechanism for the TCR‐MHC‐conserved interaction? We extend Dembic's model (Dembic Z. In, Scand J Immunol e12806, 2019) of thymus positive selection for high‐avidity anti–self‐MHC Tregs among double (CD4 + CD8+)‐positive (DP) developing thymocytes. This model is based on...

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Detalles Bibliográficos
Autores principales: Steele, Edward J., Lindley, Robyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Discussion Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064991/
https://www.ncbi.nlm.nih.gov/pubmed/31793005
http://dx.doi.org/10.1111/sji.12853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064991/
https://www.ncbi.nlm.nih.gov/pubmed/31793005
http://dx.doi.org/10.1111/sji.12853

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