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A comprehensive approach for correcting voxel‐wise b‐value errors in diffusion MRI
PURPOSE: In diffusion MRI, the actual b‐value played out on the scanner may deviate from the nominal value due to magnetic field imperfections. A simple image‐based correction method for this problem is presented. METHODS: The apparent diffusion constant (ADC) of a water phantom was measured voxel‐w...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065087/ https://www.ncbi.nlm.nih.gov/pubmed/31840300 http://dx.doi.org/10.1002/mrm.28078 |
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author | Lee, Yoojin Kettinger, Adam O. Wilm, Bertram Jakob Deichmann, Ralf Weiskopf, Nikolaus Lambert, Christian Pruessmann, Klaas Paul Nagy, Zoltan |
author_facet | Lee, Yoojin Kettinger, Adam O. Wilm, Bertram Jakob Deichmann, Ralf Weiskopf, Nikolaus Lambert, Christian Pruessmann, Klaas Paul Nagy, Zoltan |
author_sort | Lee, Yoojin |
collection | PubMed |
description | PURPOSE: In diffusion MRI, the actual b‐value played out on the scanner may deviate from the nominal value due to magnetic field imperfections. A simple image‐based correction method for this problem is presented. METHODS: The apparent diffusion constant (ADC) of a water phantom was measured voxel‐wise along 64 diffusion directions at b = 1000 s/mm(2). The true diffusion constant of water was estimated, considering the phantom temperature. A voxel‐wise correction factor, providing an effective b‐value including any magnetic field deviations, was determined for each diffusion direction by relating the measured ADC to the true diffusion constant. To test the method, the measured b‐value map was used to calculate the corrected voxel‐wise ADC for additionally acquired diffusion data sets on the same water phantom and data sets acquired on a small water phantom at three different positions. Diffusion tensor was estimated by applying the measured b‐value map to phantom and in vivo data sets. RESULTS: The b‐value‐corrected ADC maps of the phantom showed the expected spatial uniformity as well as a marked improvement in consistency across diffusion directions. The b‐value correction for the brain data resulted in a 5.8% and 5.5% decrease in mean diffusivity and angular differences of the primary diffusion direction of 2.71° and 0.73° inside gray and white matter, respectively. CONCLUSION: The actual b‐value deviates significantly from its nominal setting, leading to a spatially variable error in the common diffusion outcome measures. The suggested method measures and corrects these artifacts. |
format | Online Article Text |
id | pubmed-7065087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70650872020-03-16 A comprehensive approach for correcting voxel‐wise b‐value errors in diffusion MRI Lee, Yoojin Kettinger, Adam O. Wilm, Bertram Jakob Deichmann, Ralf Weiskopf, Nikolaus Lambert, Christian Pruessmann, Klaas Paul Nagy, Zoltan Magn Reson Med Full Papers—Imaging Methodology PURPOSE: In diffusion MRI, the actual b‐value played out on the scanner may deviate from the nominal value due to magnetic field imperfections. A simple image‐based correction method for this problem is presented. METHODS: The apparent diffusion constant (ADC) of a water phantom was measured voxel‐wise along 64 diffusion directions at b = 1000 s/mm(2). The true diffusion constant of water was estimated, considering the phantom temperature. A voxel‐wise correction factor, providing an effective b‐value including any magnetic field deviations, was determined for each diffusion direction by relating the measured ADC to the true diffusion constant. To test the method, the measured b‐value map was used to calculate the corrected voxel‐wise ADC for additionally acquired diffusion data sets on the same water phantom and data sets acquired on a small water phantom at three different positions. Diffusion tensor was estimated by applying the measured b‐value map to phantom and in vivo data sets. RESULTS: The b‐value‐corrected ADC maps of the phantom showed the expected spatial uniformity as well as a marked improvement in consistency across diffusion directions. The b‐value correction for the brain data resulted in a 5.8% and 5.5% decrease in mean diffusivity and angular differences of the primary diffusion direction of 2.71° and 0.73° inside gray and white matter, respectively. CONCLUSION: The actual b‐value deviates significantly from its nominal setting, leading to a spatially variable error in the common diffusion outcome measures. The suggested method measures and corrects these artifacts. John Wiley and Sons Inc. 2019-12-16 2020-06 /pmc/articles/PMC7065087/ /pubmed/31840300 http://dx.doi.org/10.1002/mrm.28078 Text en © 2019 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Full Papers—Imaging Methodology Lee, Yoojin Kettinger, Adam O. Wilm, Bertram Jakob Deichmann, Ralf Weiskopf, Nikolaus Lambert, Christian Pruessmann, Klaas Paul Nagy, Zoltan A comprehensive approach for correcting voxel‐wise b‐value errors in diffusion MRI |
title | A comprehensive approach for correcting voxel‐wise b‐value errors in diffusion MRI |
title_full | A comprehensive approach for correcting voxel‐wise b‐value errors in diffusion MRI |
title_fullStr | A comprehensive approach for correcting voxel‐wise b‐value errors in diffusion MRI |
title_full_unstemmed | A comprehensive approach for correcting voxel‐wise b‐value errors in diffusion MRI |
title_short | A comprehensive approach for correcting voxel‐wise b‐value errors in diffusion MRI |
title_sort | comprehensive approach for correcting voxel‐wise b‐value errors in diffusion mri |
topic | Full Papers—Imaging Methodology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065087/ https://www.ncbi.nlm.nih.gov/pubmed/31840300 http://dx.doi.org/10.1002/mrm.28078 |
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