Cargando…
Effect of screening mammography on breast cancer mortality: Quasi‐experimental evidence from rollout of the Dutch population‐based program with 17‐year follow‐up of a cohort
There is uncertainty about the magnitude of the effect of screening mammography on breast cancer mortality. The relevance and validity of evidence from dated randomized controlled trials has been questioned, whereas observational studies often lack a valid comparison group. There is no estimate of t...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065105/ https://www.ncbi.nlm.nih.gov/pubmed/31330046 http://dx.doi.org/10.1002/ijc.32584 |
_version_ | 1783504998655590400 |
---|---|
author | Van Ourti, Tom O'Donnell, Owen Koç, Hale Fracheboud, Jacques de Koning, Harry J. |
author_facet | Van Ourti, Tom O'Donnell, Owen Koç, Hale Fracheboud, Jacques de Koning, Harry J. |
author_sort | Van Ourti, Tom |
collection | PubMed |
description | There is uncertainty about the magnitude of the effect of screening mammography on breast cancer mortality. The relevance and validity of evidence from dated randomized controlled trials has been questioned, whereas observational studies often lack a valid comparison group. There is no estimate of the effect of one screening invitation only. We exploited the geographic rollout of the Dutch screening mammography program across municipalities to estimate the effects of one additional biennial screening invitation on breast cancer and all‐cause mortality. Population administrative data provided vital status and cause of death of a cohort of women aged 49–63 in 1995 over 17 years. Linear probability models were used to estimate the mortality effects. We estimated 154 fewer breast cancer deaths (95% confidence interval: 40–267; p = 0.01) over 17 years in a population of 100,000 women aged 49–63 who received one additional biennial screening invitation, which corresponds to an 9.6% risk reduction for a woman of age 56. The estimated effect on all‐cause mortality was negative but not close to statistical significance. Our study shows that one single invitation for breast cancer screening is effective in reducing breast cancer mortality, which is important for health policy. The effect is smaller than previous estimates of the effect of invitation for multiple screens, which further emphasizes the importance of achieving regular participation. |
format | Online Article Text |
id | pubmed-7065105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70651052020-03-16 Effect of screening mammography on breast cancer mortality: Quasi‐experimental evidence from rollout of the Dutch population‐based program with 17‐year follow‐up of a cohort Van Ourti, Tom O'Donnell, Owen Koç, Hale Fracheboud, Jacques de Koning, Harry J. Int J Cancer Cancer Therapy and Prevention There is uncertainty about the magnitude of the effect of screening mammography on breast cancer mortality. The relevance and validity of evidence from dated randomized controlled trials has been questioned, whereas observational studies often lack a valid comparison group. There is no estimate of the effect of one screening invitation only. We exploited the geographic rollout of the Dutch screening mammography program across municipalities to estimate the effects of one additional biennial screening invitation on breast cancer and all‐cause mortality. Population administrative data provided vital status and cause of death of a cohort of women aged 49–63 in 1995 over 17 years. Linear probability models were used to estimate the mortality effects. We estimated 154 fewer breast cancer deaths (95% confidence interval: 40–267; p = 0.01) over 17 years in a population of 100,000 women aged 49–63 who received one additional biennial screening invitation, which corresponds to an 9.6% risk reduction for a woman of age 56. The estimated effect on all‐cause mortality was negative but not close to statistical significance. Our study shows that one single invitation for breast cancer screening is effective in reducing breast cancer mortality, which is important for health policy. The effect is smaller than previous estimates of the effect of invitation for multiple screens, which further emphasizes the importance of achieving regular participation. John Wiley & Sons, Inc. 2019-08-07 2020-04-15 /pmc/articles/PMC7065105/ /pubmed/31330046 http://dx.doi.org/10.1002/ijc.32584 Text en © 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Therapy and Prevention Van Ourti, Tom O'Donnell, Owen Koç, Hale Fracheboud, Jacques de Koning, Harry J. Effect of screening mammography on breast cancer mortality: Quasi‐experimental evidence from rollout of the Dutch population‐based program with 17‐year follow‐up of a cohort |
title | Effect of screening mammography on breast cancer mortality: Quasi‐experimental evidence from rollout of the Dutch population‐based program with 17‐year follow‐up of a cohort |
title_full | Effect of screening mammography on breast cancer mortality: Quasi‐experimental evidence from rollout of the Dutch population‐based program with 17‐year follow‐up of a cohort |
title_fullStr | Effect of screening mammography on breast cancer mortality: Quasi‐experimental evidence from rollout of the Dutch population‐based program with 17‐year follow‐up of a cohort |
title_full_unstemmed | Effect of screening mammography on breast cancer mortality: Quasi‐experimental evidence from rollout of the Dutch population‐based program with 17‐year follow‐up of a cohort |
title_short | Effect of screening mammography on breast cancer mortality: Quasi‐experimental evidence from rollout of the Dutch population‐based program with 17‐year follow‐up of a cohort |
title_sort | effect of screening mammography on breast cancer mortality: quasi‐experimental evidence from rollout of the dutch population‐based program with 17‐year follow‐up of a cohort |
topic | Cancer Therapy and Prevention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065105/ https://www.ncbi.nlm.nih.gov/pubmed/31330046 http://dx.doi.org/10.1002/ijc.32584 |
work_keys_str_mv | AT vanourtitom effectofscreeningmammographyonbreastcancermortalityquasiexperimentalevidencefromrolloutofthedutchpopulationbasedprogramwith17yearfollowupofacohort AT odonnellowen effectofscreeningmammographyonbreastcancermortalityquasiexperimentalevidencefromrolloutofthedutchpopulationbasedprogramwith17yearfollowupofacohort AT kochale effectofscreeningmammographyonbreastcancermortalityquasiexperimentalevidencefromrolloutofthedutchpopulationbasedprogramwith17yearfollowupofacohort AT fracheboudjacques effectofscreeningmammographyonbreastcancermortalityquasiexperimentalevidencefromrolloutofthedutchpopulationbasedprogramwith17yearfollowupofacohort AT dekoningharryj effectofscreeningmammographyonbreastcancermortalityquasiexperimentalevidencefromrolloutofthedutchpopulationbasedprogramwith17yearfollowupofacohort |