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IGF‐1R pathway activation as putative biomarker for linsitinib therapy to revert tamoxifen resistance in ER‐positive breast cancer

Preclinical studies indicate that activated IGF‐1R can drive endocrine resistance in ER‐positive (ER+) breast cancer, but its clinical relevance is unknown. We studied the effect of IGF‐1R signaling on tamoxifen benefit in patients and we searched for approaches to overcome IGF‐1R‐mediated tamoxifen...

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Detalles Bibliográficos
Autores principales:	Kruger, Dinja T., Alexi, Xanthippi, Opdam, Mark, Schuurman, Karianne, Voorwerk, Leonie, Sanders, Joyce, van der Noort, Vincent, Boven, Epie, Zwart, Wilbert, Linn, Sabine C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2019
Materias:	Tumor Markers and Signatures
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065127/ https://www.ncbi.nlm.nih.gov/pubmed/31490549 http://dx.doi.org/10.1002/ijc.32668

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