Cargando…

Whole‐exome sequencing of ovarian cancer families uncovers putative predisposition genes

Despite the identification of several ovarian cancer (OC) predisposition genes, a large proportion of familial OC risk remains unexplained. We adopted a two‐stage design to identify new OC predisposition genes. We first carried out a large germline whole‐exome sequencing study on 158 patients from 1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Qianqian, Zhang, Jianmin, Chen, Yanmin, Hu, Qiang, Shen, He, Huang, Ruea‐Yea, Liu, Qian, Kaur, Jasmine, Long, Mark, Battaglia, Sebastiano, Eng, Kevin H., Lele, Shashikant B., Zsiros, Emese, Villella, Jeannine, Lugade, Amit, Yao, Song, Liu, Song, Moysich, Kirsten, Odunsi, Kunle O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2019
Materias:	Cancer Epidemiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065147/ https://www.ncbi.nlm.nih.gov/pubmed/31265121 http://dx.doi.org/10.1002/ijc.32545

Ejemplares similares

Whole-Genome Sequencing Identifies PPARGC1A as a Putative Modifier of Cancer Risk in BRCA1/2 Mutation Carriers
por: Zhu, Qianqian, et al.
Publicado: (2022)

Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study
por: Eng, Kevin H., et al.
Publicado: (2018)

LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8(+) T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
por: Huang, Ruea-Yea, et al.
Publicado: (2015)

Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer
por: Want, Muzamil Yaqub, et al.
Publicado: (2019)

IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation
por: Amobi-McCloud, Adaobi, et al.
Publicado: (2021)

Transmission of X-linked Ovarian Cancer: Characterization and Implications
por: Etter, John Lewis, et al.
Publicado: (2020)

Elevated Expression of the Serine-Arginine Protein Kinase 1 Gene in Ovarian Cancer and Its Role in Cisplatin Cytotoxicity In Vitro
por: Odunsi, Kunle, et al.
Publicado: (2012)

Oncolytic Maraba virus armed with tumor antigen boosts vaccine priming and reveals diverse therapeutic response patterns when combined with checkpoint blockade in ovarian cancer
por: McGray, A. J. Robert, et al.
Publicado: (2019)

Prognostic impact of adjuvant chemotherapy treatment intensity for ovarian cancer
por: Starbuck, Kristen D., et al.
Publicado: (2018)

Clonality and antigen-specific responses shape the prognostic effects of tumor-infiltrating T cells in ovarian cancer
por: Tsuji, Takemasa, et al.
Publicado: (2020)

Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer
por: Huang, Ruea-Yea, et al.
Publicado: (2016)

Identification of Claudin 6-specific HLA class I- and HLA class II-restricted T cell receptors for cellular immunotherapy in ovarian cancer
por: Matsuzaki, Junko, et al.
Publicado: (2022)

Estrogen Receptor-Beta2 (ERβ2)–Mutant p53–FOXM1 Axis: A Novel Driver of Proliferation, Chemoresistance, and Disease Progression in High Grade Serous Ovarian Cancer (HGSOC)
por: Oturkar, Chetan C., et al.
Publicado: (2022)

Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer
por: Liu, Song, et al.
Publicado: (2019)

Novel genetic variants in miR-191 gene and familial ovarian cancer
por: Shen, Jie, et al.
Publicado: (2010)

Ultrarestrictive Opioid Prescription Protocol for Pain Management After Gynecologic and Abdominal Surgery
por: Mark, Jaron, et al.
Publicado: (2018)

Microarray Analysis Reveals Distinct Gene Expression Profiles Among Different Tumor Histology, Stage and Disease Outcomes in Endometrial Adenocarcinoma
por: Mhawech-Fauceglia, Paulette, et al.
Publicado: (2010)

WHSC1/NSD2 regulates immune infiltration in prostate cancer
por: Want, Muzamil Y, et al.
Publicado: (2021)

Associations between Gene Expression Variations and Ovarian Cancer Risk Alleles Identified from Genome Wide Association Studies
por: Zhao, Hua, et al.
Publicado: (2012)

Correction: Associations between Gene Expression Variations and Ovarian Cancer Risk Alleles Identified from Genome Wide Association Studies
por: Zhao, Hua, et al.
Publicado: (2013)

Predictors of Immunosuppressive Regulatory T Lymphocytes in Healthy Women
por: Hampras, Shalaka S., et al.
Publicado: (2012)

Immuno-stimultory/regulatory gene expression patterns in advanced ovarian cancer
por: Eng, Kevin H., et al.
Publicado: (2015)

Identification of new Wilms tumour predisposition genes: an exome sequencing study
por: Mahamdallie, Shazia, et al.
Publicado: (2019)

Reprogramming the tumor microenvironment leverages CD8(+) T cell responses to a shared tumor/self antigen in ovarian cancer
por: Mistarz, Anna, et al.
Publicado: (2023)

Fidelity of human ovarian cancer patient-derived xenografts in a partially humanized mouse model for preclinical testing of immunotherapies
por: Odunsi, Adekunle, et al.
Publicado: (2020)

Expression and Immune Responses to MAGE Antigens Predict Survival in Epithelial Ovarian Cancer
por: Daudi, Sayeema, et al.
Publicado: (2014)

BiTE secretion by adoptively transferred stem-like T cells improves FRα+ ovarian cancer control
por: McGray, A J Robert, et al.
Publicado: (2023)

Identification of new breast cancer predisposition genes via whole exome sequencing
por: Southey, MC, et al.
Publicado: (2012)

Complex Segregation Analysis of Pedigrees from the Gilda Radner Familial Ovarian Cancer Registry Reveals Evidence for Mendelian Dominant Inheritance
por: Tayo, Bamidele O., et al.
Publicado: (2009)

Induction of cell death in ovarian cancer cells by doxorubicin and oncolytic vaccinia virus is associated with CREB3L1 activation
por: Mistarz, Anna, et al.
Publicado: (2021)

Whole Exome Sequencing Reveals Genetic Predisposition in a Large Family with Retinitis Pigmentosa
por: Wu, Juan, et al.
Publicado: (2014)

Whole-exome sequencing identifies novel candidate predisposition genes for familial polycythemia vera
por: Hirvonen, Elina A. M., et al.
Publicado: (2017)

Exome sequencing identifies PD‐L2 as a potential predisposition gene for lymphoma
por: Shao, Jianming, et al.
Publicado: (2022)

Germline Variants Associated with Nasopharyngeal Carcinoma Predisposition Identified through Whole-Exome Sequencing
por: Lee, Ning-Yuan, et al.
Publicado: (2022)

Evaluation of satisfaction with work–life balance among U.S. Gynecologic Oncology fellows: A cross-sectional study
por: Szender, J. Brian, et al.
Publicado: (2016)

MEDULLOBLASTOMA EXOME SEQUENCING UNCOVERS SUBTYPE-SPECIFIC SOMATIC MUTATIONS
por: Pugh, Trevor J., et al.
Publicado: (2012)

DEVOUR: Deleterious Variants on Uncovered Regions in Whole-Exome Sequencing
por: Türk, Erdem, et al.
Publicado: (2023)

Genetic Predisposition of Anti-Cytomegalovirus Immunoglobulin G Levels and the Risk of 9 Cardiovascular Diseases
por: Tan, Jiang-Shan, et al.
Publicado: (2022)

Whole Exome Sequencing Uncovered the Genetic Architecture of Growth Hormone Deficiency Patients
por: Yu, Chenxi, et al.
Publicado: (2021)

Targeting myeloid cells in the tumor microenvironment enhances vaccine efficacy in murine epithelial ovarian cancer
por: Khan, Anm Nazmul H., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7ck6b8cnq6tdn250r1iqj2im6f