Cargando…

Targeting epigenetic mechanisms as an emerging therapeutic strategy in pulmonary hypertension disease

Pulmonary arterial hypertension (PAH) is a multifactorial cardiopulmonary disease characterized by an elevation of pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR), which can lead to right ventricular (RV) failure, multi-organ dysfunction, and ultimately to premature death. De...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bisserier, Malik, Janostiak, Radoslav, Lezoualc’h, Frank, Hadri, Lahouaria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065685/ https://www.ncbi.nlm.nih.gov/pubmed/32161845 http://dx.doi.org/10.1530/VB-19-0030

Ejemplares similares

Current and emerging therapeutic approaches to pulmonary hypertension
por: Bisserier, Malik, et al.
Publicado: (2020)

Lung-targeted SERCA2a Gene Therapy: From Discovery to Therapeutic Application in Bleomycin-Induced Pulmonary Fibrosis
por: Bisserier, Malik, et al.
Publicado: (2020)

Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development
por: Dave, Jaydev, et al.
Publicado: (2023)

Molecular and Genetic Profiling for Precision Medicines in Pulmonary Arterial Hypertension
por: Fazal, Shahood, et al.
Publicado: (2021)

Novel Insights into the Therapeutic Potential of Lung-Targeted Gene Transfer in the Most Common Respiratory Diseases
por: Bisserier, Malik, et al.
Publicado: (2022)

Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19
por: Hamouche, Walid, et al.
Publicado: (2021)

Retrospective analysis of demographic factors in COVID-19 patients entering the Mount Sinai Health System
por: Eskandari, Abrisham, et al.
Publicado: (2021)

Epigenetic Mechanisms as Emerging Therapeutic Targets and Microfluidic Chips Application in Pulmonary Arterial Hypertension
por: Ho, Linh, et al.
Publicado: (2022)

Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension
por: Bisserier, Malik, et al.
Publicado: (2021)

GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure
por: Laudette, Marion, et al.
Publicado: (2021)

Role of EPAC1 Signalosomes in Cell Fate: Friends or Foes?
por: Formoso, Karina, et al.
Publicado: (2020)

The Epac1 Protein: Pharmacological Modulators, Cardiac Signalosome and Pathophysiology
por: Bouvet, Marion, et al.
Publicado: (2019)

Comorbidities, sequelae, blood biomarkers and their associated clinical outcomes in the Mount Sinai Health System COVID-19 patients
por: Brojakowska, Agnieszka, et al.
Publicado: (2021)

Epac Function and cAMP Scaffolds in the Heart and Lung
por: Laudette, Marion, et al.
Publicado: (2018)

Emerging Role of Exosomal Long Non-coding RNAs in Spaceflight-Associated Risks in Astronauts
por: Bisserier, Malik, et al.
Publicado: (2022)

Astronauts Plasma-Derived Exosomes Induced Aberrant EZH2-Mediated H3K27me3 Epigenetic Regulation of the Vitamin D Receptor
por: Bisserier, Malik, et al.
Publicado: (2022)

Author Correction: Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts
por: Brojakowska, Agnieszka, et al.
Publicado: (2022)

Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts
por: Brojakowska, Agnieszka, et al.
Publicado: (2022)

Epigenetic mechanisms of pulmonary hypertension
por: Kim, Gene H., et al.
Publicado: (2011)

Inhalable delivery of AAV-based MRP4/ABCC4 silencing RNA prevents monocrotaline-induced pulmonary hypertension
por: Claude, Caroline, et al.
Publicado: (2015)

Understanding Retinoblastoma Post-Translational Regulation for the Design of Targeted Cancer Therapies
por: Janostiak, Radoslav, et al.
Publicado: (2022)

Immunomodulation by maternal autoantibodies of the fetal serotoninergic 5-HT(4 )receptor and its consequences in early BALB/c mouse embryonic development
por: Kamel, Rehab, et al.
Publicado: (2007)

Anaplastic Lymphoma Kinase Confers Resistance to BRAF Kinase Inhibitors in Melanoma
por: Janostiak, Radoslav, et al.
Publicado: (2019)

Transcriptional regulators and alterations that drive melanoma initiation and progression
por: Gupta, Romi, et al.
Publicado: (2020)

Therapeutic Strategies in Pulmonary Hypertension
por: Fuso, Leonello, et al.
Publicado: (2011)

Cell‐Free Mitochondrial DNA as a Potential Biomarker for Astronauts' Health
por: Bisserier, Malik, et al.
Publicado: (2021)

Epigenetic Regulation and Its Therapeutic Potential in Pulmonary Hypertension
por: Wang, Yu, et al.
Publicado: (2018)

Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension
por: Watanabe, Shin, et al.
Publicado: (2018)

Inhalation of acidic nanoparticles prevents doxorubicin cardiotoxicity through improvement of lysosomal function
por: Santin, Yohan, et al.
Publicado: (2023)

Promoting Illiteracy in Epigenetics: An Emerging Therapeutic Strategy
por: Wigle, Tim J
Publicado: (2011)

Catecholamines facilitate VEGF-dependent angiogenesis via β(2)-adrenoceptor-induced Epac1 and PKA activation
por: Garg, Jaspal, et al.
Publicado: (2017)

Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics
por: Bufano, Marianna, et al.
Publicado: (2020)

Epigenetic modulation as a therapeutic approach for pulmonary arterial hypertension
por: Kim, Jun-Dae, et al.
Publicado: (2015)

Spaceflight-Associated Changes of snoRNAs in Peripheral Blood Mononuclear Cells and Plasma Exosomes—A Pilot Study
por: Rai, Amit Kumar, et al.
Publicado: (2022)

Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
por: Luna, R.C.P., et al.
Publicado: (2018)

Epigenetic Targets for Oligonucleotide Therapies of Pulmonary Arterial Hypertension
por: Gerthoffer, William
Publicado: (2020)

Inflammation, Oxidative Stress, Senescence in Atherosclerosis: Thioredoxine-1 as an Emerging Therapeutic Target
por: El Hadri, Khadija, et al.
Publicado: (2021)

Pulmonary Hypertension: Unveiling Molecular Mechanisms, Diagnosis, and Therapeutic Targets
por: Gredic, Marija, et al.
Publicado: (2023)

The Emerging Role of Epigenetics in Therapeutic Targeting of Cardiomyopathies
por: Pagiatakis, Christina, et al.
Publicado: (2021)

Therapeutic Challenges and Emerging Treatment Targets for Pulmonary Hypertension in Left Heart Disease
por: Lteif, Christelle, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_refvie1va42fuofdlkr4jnl334