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p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

The cell cycle regulator p16 is known as a biomarker and an effector of aging. However, its function in intervertebral disc degeneration (IVDD) is unclear. In this study, p16 expression levels were found to be positively correlated with the severity of human IVDD. In a mouse tail suspension (TS)-ind...

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Detalles Bibliográficos
Autores principales:	Che, Hui, Li, Jie, Li, You, Ma, Cheng, Liu, Huan, Qin, Jingyi, Dong, Jianghui, Zhang, Zhen, Xian, Cory J, Miao, Dengshun, Wang, Liping, Ren, Yongxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Human Biology and Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065909/ https://www.ncbi.nlm.nih.gov/pubmed/32125276 http://dx.doi.org/10.7554/eLife.52570

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