A myelin-related transcriptomic profile is shared between Pitt Hopkins syndrome models and human autism spectrum disorder

Autism spectrum disorder (ASD) is genetically heterogeneous with convergent symptomatology, suggesting common dysregulated pathways. We analyzed brain transcriptional changes in five mouse models of Pitt-Hopkins Syndrome (PTHS), a syndromic form of ASD caused by mutations in TCF4 (transcription fact...

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Detalles Bibliográficos
Autores principales: Phan, BaDoi N., Bohlen, Joseph F., Davis, Brittany A., Ye, Zengyou, Chen, Huei-Ying, Mayfield, Brent, Sripathy, Srinidhi Rao, Page, Stephanie Cerceo, Campbell, Morganne N., Smith, Hannah L., Gallop, Danisha, Kim, Hyojin, Thaxton, Courtney L., Simon, Jeremy M., Burke, Emily E., Shin, Joo Heon, Kennedy, Andrew J., Sweatt, J. David, Philpot, Benjamin D., Jaffe, Andrew E., Maher, Brady J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065955/
https://www.ncbi.nlm.nih.gov/pubmed/32015540
http://dx.doi.org/10.1038/s41593-019-0578-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065955/
https://www.ncbi.nlm.nih.gov/pubmed/32015540
http://dx.doi.org/10.1038/s41593-019-0578-x

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