Single cell analysis of olfactory neurogenesis and differentiation in adult humans

The presence of active neurogenic niches in adult humans remains controversial. We focused attention to human olfactory neuroepithelium (OE), an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA-sequencing analyzing 28,726 cells, we identified neural stem/p...

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Detalles Bibliográficos
Autores principales: Durante, Michael A., Kurtenbach, Stefan, Sargi, Zoukaa B., Harbour, J. William, Choi, Rhea, Kurtenbach, Sarah, Goss, Garrett M., Matsunami, Hiroaki, Goldstein, Bradley J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065961/
https://www.ncbi.nlm.nih.gov/pubmed/32066986
http://dx.doi.org/10.1038/s41593-020-0587-9
Descripción
Sumario:The presence of active neurogenic niches in adult humans remains controversial. We focused attention to human olfactory neuroepithelium (OE), an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA-sequencing analyzing 28,726 cells, we identified neural stem/progenitor cell pools and neurons. Additionally, we detailed expression of 140 olfactory receptors. These data from the OE niche provide evidence that neuron production may continue for decades in humans.

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