Single cell analysis of olfactory neurogenesis and differentiation in adult humans

The presence of active neurogenic niches in adult humans remains controversial. We focused attention to human olfactory neuroepithelium (OE), an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA-sequencing analyzing 28,726 cells, we identified neural stem/p...

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Autores principales: Durante, Michael A., Kurtenbach, Stefan, Sargi, Zoukaa B., Harbour, J. William, Choi, Rhea, Kurtenbach, Sarah, Goss, Garrett M., Matsunami, Hiroaki, Goldstein, Bradley J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065961/
https://www.ncbi.nlm.nih.gov/pubmed/32066986
http://dx.doi.org/10.1038/s41593-020-0587-9
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author Durante, Michael A.
Kurtenbach, Stefan
Sargi, Zoukaa B.
Harbour, J. William
Choi, Rhea
Kurtenbach, Sarah
Goss, Garrett M.
Matsunami, Hiroaki
Goldstein, Bradley J.
author_facet Durante, Michael A.
Kurtenbach, Stefan
Sargi, Zoukaa B.
Harbour, J. William
Choi, Rhea
Kurtenbach, Sarah
Goss, Garrett M.
Matsunami, Hiroaki
Goldstein, Bradley J.
author_sort Durante, Michael A.
collection PubMed
description The presence of active neurogenic niches in adult humans remains controversial. We focused attention to human olfactory neuroepithelium (OE), an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA-sequencing analyzing 28,726 cells, we identified neural stem/progenitor cell pools and neurons. Additionally, we detailed expression of 140 olfactory receptors. These data from the OE niche provide evidence that neuron production may continue for decades in humans.
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spelling pubmed-70659612020-08-17 Single cell analysis of olfactory neurogenesis and differentiation in adult humans Durante, Michael A. Kurtenbach, Stefan Sargi, Zoukaa B. Harbour, J. William Choi, Rhea Kurtenbach, Sarah Goss, Garrett M. Matsunami, Hiroaki Goldstein, Bradley J. Nat Neurosci Article The presence of active neurogenic niches in adult humans remains controversial. We focused attention to human olfactory neuroepithelium (OE), an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA-sequencing analyzing 28,726 cells, we identified neural stem/progenitor cell pools and neurons. Additionally, we detailed expression of 140 olfactory receptors. These data from the OE niche provide evidence that neuron production may continue for decades in humans. 2020-02-17 2020-03 /pmc/articles/PMC7065961/ /pubmed/32066986 http://dx.doi.org/10.1038/s41593-020-0587-9 Text en Reprints and permissions information is available at www.nature.com/reprints (http://www.nature.com/reprints) . Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Durante, Michael A.
Kurtenbach, Stefan
Sargi, Zoukaa B.
Harbour, J. William
Choi, Rhea
Kurtenbach, Sarah
Goss, Garrett M.
Matsunami, Hiroaki
Goldstein, Bradley J.
Single cell analysis of olfactory neurogenesis and differentiation in adult humans
title Single cell analysis of olfactory neurogenesis and differentiation in adult humans
title_full Single cell analysis of olfactory neurogenesis and differentiation in adult humans
title_fullStr Single cell analysis of olfactory neurogenesis and differentiation in adult humans
title_full_unstemmed Single cell analysis of olfactory neurogenesis and differentiation in adult humans
title_short Single cell analysis of olfactory neurogenesis and differentiation in adult humans
title_sort single cell analysis of olfactory neurogenesis and differentiation in adult humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065961/
https://www.ncbi.nlm.nih.gov/pubmed/32066986
http://dx.doi.org/10.1038/s41593-020-0587-9
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