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A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations
In the primitive era, humans benefited partially from plants and metals to treat microbial infections. Later these infections were cured with antibiotics but further suffered from resistance issues. In searching of an alternative, researchers developed an adjuvant therapy but were hampered by spread...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shenyang Pharmaceutical University
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066045/ https://www.ncbi.nlm.nih.gov/pubmed/32175017 http://dx.doi.org/10.1016/j.ajps.2019.03.002 |
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author | Ruddaraju, Lakshmi Kalyani Pammi, Sri Venkata Narayana Guntuku, Girija sankar Padavala, Veerabhadra Swamy Kolapalli, Venkata Ramana Murthy |
author_facet | Ruddaraju, Lakshmi Kalyani Pammi, Sri Venkata Narayana Guntuku, Girija sankar Padavala, Veerabhadra Swamy Kolapalli, Venkata Ramana Murthy |
author_sort | Ruddaraju, Lakshmi Kalyani |
collection | PubMed |
description | In the primitive era, humans benefited partially from plants and metals to treat microbial infections. Later these infections were cured with antibiotics but further suffered from resistance issues. In searching of an alternative, researchers developed an adjuvant therapy but were hampered by spreading resistance. Subsequently, nanoparticles (NPs) were proposed to cease the multi-drug resistant bacteria but were hindered due to toxicity issues. Recently, a novel adjuvant therapy employed metals and botanicals into innovative nanotechnology as nano-antibiotics. The combination of green synthesized metallic NPs with antibiotics seems to be a viable platform to combat against MDR bacteria by alleviating resistance and toxicity. This review focuses on the primitive to present era dealings with bacterial resistance mechanisms, newer innovations of nanotechnology and their multiple mechanisms to combat resistance. In addition, special focus is paid on greener NPs as antibiotic carriers, and their future prospects of controlled release and toxicity study. |
format | Online Article Text |
id | pubmed-7066045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Shenyang Pharmaceutical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-70660452020-03-13 A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations Ruddaraju, Lakshmi Kalyani Pammi, Sri Venkata Narayana Guntuku, Girija sankar Padavala, Veerabhadra Swamy Kolapalli, Venkata Ramana Murthy Asian J Pharm Sci Review article In the primitive era, humans benefited partially from plants and metals to treat microbial infections. Later these infections were cured with antibiotics but further suffered from resistance issues. In searching of an alternative, researchers developed an adjuvant therapy but were hampered by spreading resistance. Subsequently, nanoparticles (NPs) were proposed to cease the multi-drug resistant bacteria but were hindered due to toxicity issues. Recently, a novel adjuvant therapy employed metals and botanicals into innovative nanotechnology as nano-antibiotics. The combination of green synthesized metallic NPs with antibiotics seems to be a viable platform to combat against MDR bacteria by alleviating resistance and toxicity. This review focuses on the primitive to present era dealings with bacterial resistance mechanisms, newer innovations of nanotechnology and their multiple mechanisms to combat resistance. In addition, special focus is paid on greener NPs as antibiotic carriers, and their future prospects of controlled release and toxicity study. Shenyang Pharmaceutical University 2020-01 2019-06-12 /pmc/articles/PMC7066045/ /pubmed/32175017 http://dx.doi.org/10.1016/j.ajps.2019.03.002 Text en © 2019 Shenyang Pharmaceutical University. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review article Ruddaraju, Lakshmi Kalyani Pammi, Sri Venkata Narayana Guntuku, Girija sankar Padavala, Veerabhadra Swamy Kolapalli, Venkata Ramana Murthy A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations |
title | A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations |
title_full | A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations |
title_fullStr | A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations |
title_full_unstemmed | A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations |
title_short | A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations |
title_sort | review on anti-bacterials to combat resistance: from ancient era of plants and metals to present and future perspectives of green nano technological combinations |
topic | Review article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066045/ https://www.ncbi.nlm.nih.gov/pubmed/32175017 http://dx.doi.org/10.1016/j.ajps.2019.03.002 |
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