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A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations

In the primitive era, humans benefited partially from plants and metals to treat microbial infections. Later these infections were cured with antibiotics but further suffered from resistance issues. In searching of an alternative, researchers developed an adjuvant therapy but were hampered by spread...

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Autores principales: Ruddaraju, Lakshmi Kalyani, Pammi, Sri Venkata Narayana, Guntuku, Girija sankar, Padavala, Veerabhadra Swamy, Kolapalli, Venkata Ramana Murthy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066045/
https://www.ncbi.nlm.nih.gov/pubmed/32175017
http://dx.doi.org/10.1016/j.ajps.2019.03.002
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author Ruddaraju, Lakshmi Kalyani
Pammi, Sri Venkata Narayana
Guntuku, Girija sankar
Padavala, Veerabhadra Swamy
Kolapalli, Venkata Ramana Murthy
author_facet Ruddaraju, Lakshmi Kalyani
Pammi, Sri Venkata Narayana
Guntuku, Girija sankar
Padavala, Veerabhadra Swamy
Kolapalli, Venkata Ramana Murthy
author_sort Ruddaraju, Lakshmi Kalyani
collection PubMed
description In the primitive era, humans benefited partially from plants and metals to treat microbial infections. Later these infections were cured with antibiotics but further suffered from resistance issues. In searching of an alternative, researchers developed an adjuvant therapy but were hampered by spreading resistance. Subsequently, nanoparticles (NPs) were proposed to cease the multi-drug resistant bacteria but were hindered due to toxicity issues. Recently, a novel adjuvant therapy employed metals and botanicals into innovative nanotechnology as nano-antibiotics. The combination of green synthesized metallic NPs with antibiotics seems to be a viable platform to combat against MDR bacteria by alleviating resistance and toxicity. This review focuses on the primitive to present era dealings with bacterial resistance mechanisms, newer innovations of nanotechnology and their multiple mechanisms to combat resistance. In addition, special focus is paid on greener NPs as antibiotic carriers, and their future prospects of controlled release and toxicity study.
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spelling pubmed-70660452020-03-13 A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations Ruddaraju, Lakshmi Kalyani Pammi, Sri Venkata Narayana Guntuku, Girija sankar Padavala, Veerabhadra Swamy Kolapalli, Venkata Ramana Murthy Asian J Pharm Sci Review article In the primitive era, humans benefited partially from plants and metals to treat microbial infections. Later these infections were cured with antibiotics but further suffered from resistance issues. In searching of an alternative, researchers developed an adjuvant therapy but were hampered by spreading resistance. Subsequently, nanoparticles (NPs) were proposed to cease the multi-drug resistant bacteria but were hindered due to toxicity issues. Recently, a novel adjuvant therapy employed metals and botanicals into innovative nanotechnology as nano-antibiotics. The combination of green synthesized metallic NPs with antibiotics seems to be a viable platform to combat against MDR bacteria by alleviating resistance and toxicity. This review focuses on the primitive to present era dealings with bacterial resistance mechanisms, newer innovations of nanotechnology and their multiple mechanisms to combat resistance. In addition, special focus is paid on greener NPs as antibiotic carriers, and their future prospects of controlled release and toxicity study. Shenyang Pharmaceutical University 2020-01 2019-06-12 /pmc/articles/PMC7066045/ /pubmed/32175017 http://dx.doi.org/10.1016/j.ajps.2019.03.002 Text en © 2019 Shenyang Pharmaceutical University. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review article
Ruddaraju, Lakshmi Kalyani
Pammi, Sri Venkata Narayana
Guntuku, Girija sankar
Padavala, Veerabhadra Swamy
Kolapalli, Venkata Ramana Murthy
A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations
title A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations
title_full A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations
title_fullStr A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations
title_full_unstemmed A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations
title_short A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations
title_sort review on anti-bacterials to combat resistance: from ancient era of plants and metals to present and future perspectives of green nano technological combinations
topic Review article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066045/
https://www.ncbi.nlm.nih.gov/pubmed/32175017
http://dx.doi.org/10.1016/j.ajps.2019.03.002
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