Defective Interferon Gamma Production by Tumor-Specific CD8(+) T Cells Is Associated With 5′Methylcytosine-Guanine Hypermethylation of Interferon Gamma Promoter

Interferon gamma (IFNγ) supports effector responses of CD8(+) cytotoxic T lymphocytes (CTLs) and is a surrogate marker for detection of antigen-specific T cells. Here, we show that tumor-specific CTL clones have impaired IFNγ expression and production upon activation. Assessment of the relationship...

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Detalles Bibliográficos
Autores principales: Abd Hamid, Megat, Yao, Xuan, Waugh, Craig, Rosendo-Machado, Samara, Li, Chris, Rostron, Timothy, Frankland, John, Peng, Yanchun, Dong, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066077/
https://www.ncbi.nlm.nih.gov/pubmed/32194559
http://dx.doi.org/10.3389/fimmu.2020.00310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066077/
https://www.ncbi.nlm.nih.gov/pubmed/32194559
http://dx.doi.org/10.3389/fimmu.2020.00310

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