Cargando…
Defective Interferon Gamma Production by Tumor-Specific CD8(+) T Cells Is Associated With 5′Methylcytosine-Guanine Hypermethylation of Interferon Gamma Promoter
Interferon gamma (IFNγ) supports effector responses of CD8(+) cytotoxic T lymphocytes (CTLs) and is a surrogate marker for detection of antigen-specific T cells. Here, we show that tumor-specific CTL clones have impaired IFNγ expression and production upon activation. Assessment of the relationship...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066077/ https://www.ncbi.nlm.nih.gov/pubmed/32194559 http://dx.doi.org/10.3389/fimmu.2020.00310 |