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T-Cell Receptor Variable β Domains Rigidify During Affinity Maturation

We investigated T-cell receptor variable β chains binding to the superantigen staphylococcal enterotoxin C3 (SEC 3) with structure information in different stages of affinity maturation. Metadynamics in combination with molecular dynamics simulations allow to access the micro-to-millisecond timescal...

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Detalles Bibliográficos
Autores principales:	Fernández-Quintero, Monica L., Seidler, Clarissa A., Liedl, Klaus R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066139/ https://www.ncbi.nlm.nih.gov/pubmed/32161287 http://dx.doi.org/10.1038/s41598-020-61433-0

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