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Adaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life

Interferon regulatory factor 3 (IRF3) and IRF7 are closely related IRF members and the major factors for the induction of interferons, a key component in vertebrate innate immunity. However, there is limited knowledge regarding the evolution and adaptation of those IRFs to the environments. Two uniq...

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Autores principales: Angeletti, Monica, Hsu, Wan-Ling Nicole, Majo, Nashaat, Moriyama, Hideaki, Moriyama, Etsuko N., Zhang, Luwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066157/
https://www.ncbi.nlm.nih.gov/pubmed/32161340
http://dx.doi.org/10.1038/s41598-020-61365-9
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author Angeletti, Monica
Hsu, Wan-Ling Nicole
Majo, Nashaat
Moriyama, Hideaki
Moriyama, Etsuko N.
Zhang, Luwen
author_facet Angeletti, Monica
Hsu, Wan-Ling Nicole
Majo, Nashaat
Moriyama, Hideaki
Moriyama, Etsuko N.
Zhang, Luwen
author_sort Angeletti, Monica
collection PubMed
description Interferon regulatory factor 3 (IRF3) and IRF7 are closely related IRF members and the major factors for the induction of interferons, a key component in vertebrate innate immunity. However, there is limited knowledge regarding the evolution and adaptation of those IRFs to the environments. Two unique motifs in IRF3 and 7 were identified. One motif, GASSL, is highly conserved throughout the evolution of IRF3 and 7 and located in the signal response domain. Another motif, DPHK, is in the DNA-binding domain. The ancestral protein of IRF3 and 7 seemed to possess the DPHK motif. In the ray-finned fish lineage, while the DPHK is maintained in IRF7, the motif in IRF3 is changed to NPHK with a D → N amino acid substitution. The D → N substitution are also found in amphibian IRF3 but not in amphibian IRF7. Terrestrial animals such as reptiles and mammals predominantly use DPHK sequences in both IRF3 and 7. However, the D → N substitution in IRF3 DPHK is again found in cetaceans such as whales and dolphins as well as in marsupials. These observations suggest that the D → N substitutions in the IRF3 DPHK motif is likely to be associated with vertebrate’s adaptations to aquatic environments and other environmental changes.
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spelling pubmed-70661572020-03-19 Adaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life Angeletti, Monica Hsu, Wan-Ling Nicole Majo, Nashaat Moriyama, Hideaki Moriyama, Etsuko N. Zhang, Luwen Sci Rep Article Interferon regulatory factor 3 (IRF3) and IRF7 are closely related IRF members and the major factors for the induction of interferons, a key component in vertebrate innate immunity. However, there is limited knowledge regarding the evolution and adaptation of those IRFs to the environments. Two unique motifs in IRF3 and 7 were identified. One motif, GASSL, is highly conserved throughout the evolution of IRF3 and 7 and located in the signal response domain. Another motif, DPHK, is in the DNA-binding domain. The ancestral protein of IRF3 and 7 seemed to possess the DPHK motif. In the ray-finned fish lineage, while the DPHK is maintained in IRF7, the motif in IRF3 is changed to NPHK with a D → N amino acid substitution. The D → N substitution are also found in amphibian IRF3 but not in amphibian IRF7. Terrestrial animals such as reptiles and mammals predominantly use DPHK sequences in both IRF3 and 7. However, the D → N substitution in IRF3 DPHK is again found in cetaceans such as whales and dolphins as well as in marsupials. These observations suggest that the D → N substitutions in the IRF3 DPHK motif is likely to be associated with vertebrate’s adaptations to aquatic environments and other environmental changes. Nature Publishing Group UK 2020-03-11 /pmc/articles/PMC7066157/ /pubmed/32161340 http://dx.doi.org/10.1038/s41598-020-61365-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Angeletti, Monica
Hsu, Wan-Ling Nicole
Majo, Nashaat
Moriyama, Hideaki
Moriyama, Etsuko N.
Zhang, Luwen
Adaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life
title Adaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life
title_full Adaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life
title_fullStr Adaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life
title_full_unstemmed Adaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life
title_short Adaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life
title_sort adaptations of interferon regulatory factor 3 with transition from terrestrial to aquatic life
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066157/
https://www.ncbi.nlm.nih.gov/pubmed/32161340
http://dx.doi.org/10.1038/s41598-020-61365-9
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