Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy

The integrated stress response (ISR) converges on eIF2α phosphorylation to regulate protein synthesis. ISR is activated by several stress conditions, including endoplasmic reticulum (ER) stress, executed by protein kinase R-like endoplasmic reticulum kinase (PERK). We report that ER stress combined...

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Detalles Bibliográficos
Autores principales: Mahameed, Mohamed, Boukeileh, Shatha, Obiedat, Akram, Darawshi, Odai, Dipta, Priya, Rimon, Amit, McLennan, Gordon, Fassler, Rosi, Reichmann, Dana, Karni, Rotem, Preisinger, Christian, Wilhelm, Thomas, Huber, Michael, Tirosh, Boaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066181/
https://www.ncbi.nlm.nih.gov/pubmed/32161259
http://dx.doi.org/10.1038/s41467-020-15067-5

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