Chemical modification of melphalan as a key to improving treatment of haematological malignancies

Chemical modification of known, effective drugs is one method to improve chemotherapy. Thus, the object of this study was to generate melphalan derivatives with improved cytotoxic activity in human cancer cells (RPMI8226, HL60 and THP1). Several melphalan derivatives were synthesised, modified in th...

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Detalles Bibliográficos
Autores principales: Gajek, Arkadiusz, Poczta, Anastazja, Łukawska, Małgorzata, Cecuda- Adamczewska, Violetta, Tobiasz, Joanna, Marczak, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066245/
https://www.ncbi.nlm.nih.gov/pubmed/32161295
http://dx.doi.org/10.1038/s41598-020-61436-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066245/
https://www.ncbi.nlm.nih.gov/pubmed/32161295
http://dx.doi.org/10.1038/s41598-020-61436-x

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