Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation

Aberrant neuronal development and the persistence of mitotic cellular populations have been implicated in a multitude of neurological disorders, including Huntington's disease (HD). However, the mechanism underlying this potential pathology remains unclear. We used a modified protocol to differ...

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Detalles Bibliográficos
Autores principales: Smith-Geater, Charlene, Hernandez, Sarah J., Lim, Ryan G., Adam, Miriam, Wu, Jie, Stocksdale, Jennifer T., Wassie, Brook T., Gold, Maxwell Philip, Wang, Keona Q., Miramontes, Ricardo, Kopan, Lexi, Orellana, Iliana, Joy, Shona, Kemp, Paul J., Allen, Nicholas D., Fraenkel, Ernest, Thompson, Leslie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066322/
https://www.ncbi.nlm.nih.gov/pubmed/32109367
http://dx.doi.org/10.1016/j.stemcr.2020.01.015

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