Cargando…

Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma

Various populations of cancer stem cells (CSCs) have been identified in hepatocellular carcinoma (HCC). Wnt signaling is variably activated in HCC and regulates CSCs and tumorigenesis. We explored cell-to-cell Wnt and stemness heterogeneity in HCC by labeling freshly isolated cancer cells with a Wnt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liao, Wen-Ying, Hsu, Chung-Chi, Chan, Tze-Sian, Yen, Chia-Jui, Chen, Wei-Yu, Pan, Hung-Wei, Tsai, Kelvin K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066362/ https://www.ncbi.nlm.nih.gov/pubmed/32160521 http://dx.doi.org/10.1016/j.stemcr.2020.02.003

Ejemplares similares

Dishevelling Wnt and Hippo
por: Kim, Nam Hee, et al.
Publicado: (2018)

The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosis
por: Hsu, Chung‐Chi, et al.
Publicado: (2019)

Dishevelled and Wnt signaling: is the nucleus the final frontier?
por: Habas, Raymond, et al.
Publicado: (2005)

Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway
por: Lo, Regina Cheuk-Lam, et al.
Publicado: (2018)

Llama-Derived Single Domain Antibodies to Build Multivalent, Superpotent and Broadened Neutralizing Anti-Viral Molecules
por: Hultberg, Anna, et al.
Publicado: (2011)

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling
por: Jung, H, et al.
Publicado: (2013)

Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled
por: Gammons, Melissa V., et al.
Publicado: (2016)

CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis
por: Sun, Huaqin, et al.
Publicado: (2018)

Decoding Dishevelled-Mediated Wnt Signaling in Vertebrate Early Development
por: Shi, De-Li
Publicado: (2020)

Selective function of the PDZ domain of Dishevelled in noncanonical Wnt signalling
por: Mieszczanek, Juliusz, et al.
Publicado: (2022)

Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling
por: Itoh, Keiji, et al.
Publicado: (2005)

Colocalization and Redistribution of Dishevelled and Actin during WNT-Induced Mesenchymal Morphogenesis
por: Torres, Monica A., et al.
Publicado: (2000)

Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation
por: Ma, Wenzhe, et al.
Publicado: (2020)

Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction
por: Kan, Wei, et al.
Publicado: (2020)

IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling
por: Goto, Toshiyasu, et al.
Publicado: (2013)

Epsin is required for Dishevelled stability and Wnt signaling activation in colon cancer development
por: Chang, Baojun, et al.
Publicado: (2015)

Membrane Bound GSK-3 Activates Wnt Signaling through Disheveled and Arrow
por: Mannava, Anirudh G., et al.
Publicado: (2015)

Activity of Smurf2 Ubiquitin Ligase Is Regulated by the Wnt Pathway Protein Dishevelled
por: Bernatik, Ondrej, et al.
Publicado: (2020)

Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly
por: Kang, Kexin, et al.
Publicado: (2022)

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
por: Kamdem, Nestor, et al.
Publicado: (2021)

Inhibition of Dishevelled-2 suppresses the biological behavior of pancreatic cancer by downregulating Wnt/β-catenin signaling
por: Hu, Wei, et al.
Publicado: (2021)

Dishevelled nuclear shuttling
por: Weitzman, Jonathan B
Publicado: (2005)

Origin and Evolution of Dishevelled
por: Dillman, Adler R., et al.
Publicado: (2013)

The cellular story of dishevelleds
por: Kafka, Anja, et al.
Publicado: (2014)

Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release
por: Ahmad-Annuar, Azlina, et al.
Publicado: (2006)

Wnt signalling antagonizes stress granule assembly through a Dishevelled-dependent mechanism
por: Sahoo, Pabitra K., et al.
Publicado: (2011)

Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways
por: Lee, Ho-Jin, et al.
Publicado: (2015)

Reversible acetylation modulates dishevelled-2 puncta formation in canonical Wnt signaling activation
por: Shen, Jinhong, et al.
Publicado: (2020)

Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling
por: Sharma, Monica, et al.
Publicado: (2021)

Genetic Analysis of Disheveled 2 and Disheveled 3 in Human Neural Tube Defects
por: De Marco, Patrizia, et al.
Publicado: (2012)

PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling
por: Shah, Adnan Shami, et al.
Publicado: (2019)

The nanoscale organization of the Wnt signaling integrator Dishevelled in the vegetal cortex domain of an egg and early embryo
por: Henson, John H., et al.
Publicado: (2021)

Phosphoprotein phosphatase-2A docks to Dishevelled and counterregulates Wnt3a/β-catenin signaling
por: Yokoyama, Noriko, et al.
Publicado: (2007)

Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay
por: Gammons, Melissa V., et al.
Publicado: (2016)

The N-Terminal Part of the Dishevelled DEP Domain Is Required for Wnt/β-Catenin Signaling in Mammalian Cells
por: Paclíková, Petra, et al.
Publicado: (2017)

Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling
por: Yoon, Jaeho, et al.
Publicado: (2023)

Systematic summarization of the expression profiles and prognostic roles of the dishevelled gene family in hepatocellular carcinoma
por: Mei, Jie, et al.
Publicado: (2020)

The distribution of Dishevelled in convergently extending mesoderm()
por: Panousopoulou, Eleni, et al.
Publicado: (2013)

PTEN regulates cilia through Dishevelled
por: Shnitsar, Iryna, et al.
Publicado: (2015)

Upregulation of MicroRNA-19b predicts good prognosis in patients with hepatocellular carcinoma presenting with vascular invasion or multifocal disease
por: Hung, Chung-Lin, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_g7n6fbourqig0ebc7c7ab8grb1