Corrosion Resistance and Biocompatibility Assessment of a Biodegradable Hydrothermal-Coated Mg–Zn–Ca Alloy: An in Vitro and in Vivo Study

[Image: see text] A hydrothermal (HT) coating was applied to the biomedical Mg–Zn–Ca alloy surface by microarc oxidation (MAO) and heat treatment. Then, the corrosion resistance and biocompatibility of the coated alloy was evaluated in vitro and in vivo. The corrosion rate (CR) of HT-coated implants was significantly lower in experiment. In addition, this CR increased over time in vivo but was stable, albeit higher, in vitro. The proliferation, adhesion, and live activity of bone marrow stem cells (BMSCs) were significantly greater on the surface of the HT-coated Mg alloy in vitro. Serum Mg(2+) was always within the normal range in rabbits with implants, although Ca(2+) was higher than normal for both uncoated and coated scaffolds. There were no significant pathological effects on the main organs of alloy-implanted rabbits compared with healthy animals. Thus, the HT coating significantly improved the corrosion resistance and biocompatibility of the Mg–Zn–Ca alloy.