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Chemokines—What Is Their Role in Colorectal Cancer?

Colorectal cancer (CRC) is one of the leading causes of cancer-related death. It is the second most frequently diagnosed malignancy in Europe and third worldwide. Colorectal malignancies diagnosed at an early stage offer a promising survival rate. However, advanced tumors often present distant metas...

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Autores principales: Pączek, Sara, Łukaszewicz-Zając, Marta, Mroczko, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066593/
https://www.ncbi.nlm.nih.gov/pubmed/32103675
http://dx.doi.org/10.1177/1073274820903384
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author Pączek, Sara
Łukaszewicz-Zając, Marta
Mroczko, Barbara
author_facet Pączek, Sara
Łukaszewicz-Zając, Marta
Mroczko, Barbara
author_sort Pączek, Sara
collection PubMed
description Colorectal cancer (CRC) is one of the leading causes of cancer-related death. It is the second most frequently diagnosed malignancy in Europe and third worldwide. Colorectal malignancies diagnosed at an early stage offer a promising survival rate. However, advanced tumors often present distant metastases even after the complete resection of a primary tumor. Therefore, novel biomarkers of CRC are sorely needed in the diagnosis and prognosis of this common malignancy. A family of chemokines are composed of small, secreted proteins. They are best known for their ability to stimulate the migration of several cell types. Some investigations have indicated that chemokines are involved in cancer development, including CRC. This article presents current knowledge regarding chemokines and their specific receptors in CRC progression. Moreover, the prime aim of this review is to summarize the potential role of these proteins as biomarkers in the diagnosis and prognosis of CRC.
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spelling pubmed-70665932020-03-20 Chemokines—What Is Their Role in Colorectal Cancer? Pączek, Sara Łukaszewicz-Zając, Marta Mroczko, Barbara Cancer Control Review Colorectal cancer (CRC) is one of the leading causes of cancer-related death. It is the second most frequently diagnosed malignancy in Europe and third worldwide. Colorectal malignancies diagnosed at an early stage offer a promising survival rate. However, advanced tumors often present distant metastases even after the complete resection of a primary tumor. Therefore, novel biomarkers of CRC are sorely needed in the diagnosis and prognosis of this common malignancy. A family of chemokines are composed of small, secreted proteins. They are best known for their ability to stimulate the migration of several cell types. Some investigations have indicated that chemokines are involved in cancer development, including CRC. This article presents current knowledge regarding chemokines and their specific receptors in CRC progression. Moreover, the prime aim of this review is to summarize the potential role of these proteins as biomarkers in the diagnosis and prognosis of CRC. SAGE Publications 2020-02-27 /pmc/articles/PMC7066593/ /pubmed/32103675 http://dx.doi.org/10.1177/1073274820903384 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Pączek, Sara
Łukaszewicz-Zając, Marta
Mroczko, Barbara
Chemokines—What Is Their Role in Colorectal Cancer?
title Chemokines—What Is Their Role in Colorectal Cancer?
title_full Chemokines—What Is Their Role in Colorectal Cancer?
title_fullStr Chemokines—What Is Their Role in Colorectal Cancer?
title_full_unstemmed Chemokines—What Is Their Role in Colorectal Cancer?
title_short Chemokines—What Is Their Role in Colorectal Cancer?
title_sort chemokines—what is their role in colorectal cancer?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066593/
https://www.ncbi.nlm.nih.gov/pubmed/32103675
http://dx.doi.org/10.1177/1073274820903384
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