Cargando…

Cysteine-to-lysine transfer antibody fragment conjugation

The modification of lysine residues with acylating agents has represented a ubiquitous approach to the construction of antibody conjugates, with the resulting amide bonds being robustly stable and clinically validated. However, the conjugates are highly heterogeneous, due to the presence of numerous...

Descripción completa

Detalles Bibliográficos
Autores principales:	Forte, Nafsika, Benni, Irene, Karu, Kersti, Chudasama, Vijay, Baker, James R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066670/ https://www.ncbi.nlm.nih.gov/pubmed/32190247 http://dx.doi.org/10.1039/c9sc03825f

Ejemplares similares

Site-selective lysine conjugation methods and applications towards antibody–drug conjugates
por: Haque, Muhammed, et al.
Publicado: (2021)

Correction: Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation
por: Bahou, Calise, et al.
Publicado: (2022)

Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4
por: Maneiro, María, et al.
Publicado: (2020)

Forming next-generation antibody–nanoparticle conjugates through the oriented installation of non-engineered antibody fragments
por: Greene, Michelle K., et al.
Publicado: (2017)

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine
por: Smith, Mark E. B., et al.
Publicado: (2015)

Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation
por: Chrzastek, Alina, et al.
Publicado: (2022)

Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering
por: Lee, Maximillian T. W., et al.
Publicado: (2017)

One-pot thiol–amine bioconjugation to maleimides: simultaneous stabilisation and dual functionalisation
por: Wall, Archie, et al.
Publicado: (2020)

Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones
por: Bahou, Calise, et al.
Publicado: (2018)

Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation
por: Castañeda, Lourdes, et al.
Publicado: (2013)

Antibody fragments as nanoparticle targeting ligands: a step in the right direction
por: Richards, Daniel A., et al.
Publicado: (2017)

Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs)
por: Thoreau, Fabien, et al.
Publicado: (2023)

Characterizing and understanding the formation of cysteine conjugates and other by-products in a random, lysine-linked antibody drug conjugate
por: Qiu, Difei, et al.
Publicado: (2021)

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging
por: Schumacher, Felix F., et al.
Publicado: (2014)

Cysteine specific bioconjugation with benzyl isothiocyanates
por: Petri, László, et al.
Publicado: (2020)

Investigating the Impact of Sample Preparation on Mass Spectrometry-Based Drug-To-Antibody Ratio Determination for Cysteine- and Lysine-Linked Antibody–Drug Conjugates
por: Källsten, Malin, et al.
Publicado: (2020)

In Vitro Characterization and Stability Profiles of Antibody–Fluorophore Conjugates Derived from Interchain Cysteine Cross-Linking or Lysine Bioconjugation
por: Martin, Camille, et al.
Publicado: (2019)

Epsilon-poly-l-lysine conjugated erythromycin for enhanced antibiotic therapy
por: Yu, Jie, et al.
Publicado: (2023)

Intra-Domain Cysteines (IDC), a New Strategy for the Development of Original Antibody Fragment–Drug Conjugates (FDCs)
por: Jolivet, Louis, et al.
Publicado: (2022)

A novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification
por: Nathani, Ramiz I., et al.
Publicado: (2013)

New Bifunctional Chelators Incorporating Dibromomaleimide Groups for Radiolabeling of Antibodies with Positron Emission Tomography Imaging Radioisotopes
por: Farleigh, Matthew, et al.
Publicado: (2021)

Non-ergodic fragmentation upon collision-induced activation of cysteine–water cluster cations
por: Tiefenthaler, Lukas, et al.
Publicado: (2023)

A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation
por: Morgan, Rachel E., et al.
Publicado: (2015)

Rapid Evaluation of Antibody Fragment Endocytosis for Antibody Fragment–Drug Conjugates
por: Kim, Eunhee G., et al.
Publicado: (2020)

Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors
por: Keeley, A., et al.
Publicado: (2018)

Dual-mechanistic antibody-drug conjugate via site-specific selenocysteine/cysteine conjugation
por: Nilchan, Napon, et al.
Publicado: (2019)

Excimer based fluorescent pyrene–ferritin conjugate for protein oligomerization studies and imaging in living cells
por: Benni, Irene, et al.
Publicado: (2018)

Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics'
por: Schumacher, Felix F., et al.
Publicado: (2013)

Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments
por: Mantaj, Julia, et al.
Publicado: (2016)

Enabling the next steps in cancer immunotherapy: from antibody-based bispecifics to multispecifics, with an evolving role for bioconjugation chemistry
por: Thoreau, Fabien, et al.
Publicado: (2021)

Site-Specific Antibody Conjugation to Engineered Double Cysteine Residues
por: Zhou, Qun, et al.
Publicado: (2021)

In Vitro and In Vivo Evaluation of Cysteine and Site Specific Conjugated Herceptin Antibody-Drug Conjugates
por: Jackson, Dowdy, et al.
Publicado: (2014)

Context‐Dependence of the Reactivity of Cysteine and Lysine Residues
por: Boll, Linus B., et al.
Publicado: (2022)

Ethynylphosphonamidates for the Rapid and Cysteine‐Selective Generation of Efficacious Antibody–Drug Conjugates
por: Kasper, Marc‐André, et al.
Publicado: (2019)

Synthesis of BINOL–xylose-conjugates as “Turn-off” fluorescent receptors for Fe(3+) and secondary recognition of cysteine by their complexes
por: Wang, Huizhen, et al.
Publicado: (2022)

Sulfatase-cleavable linkers for antibody-drug conjugates
por: Bargh, Jonathan D., et al.
Publicado: (2020)

Peroxide-cleavable linkers for antibody–drug conjugates
por: Ashman, Nicola, et al.
Publicado: (2023)

Quantifying internal charge transfer and mixed ion-electron transfer in conjugated radical polymers
por: Wang, Shaoyang, et al.
Publicado: (2020)

Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit
por: Cooper, Chris E., et al.
Publicado: (2021)

Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker
por: Filntisi, Arianna, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_o6r5mhd2fd6vc5cepdsufoagv1