Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography

Oligodeoxynucleotides incorporating internucleotide phosphoroselenolate linkages have been prepared under solid-phase synthesis conditions using dimer phosphoramidites. These dimers were constructed following the high yielding Michaelis–Arbuzov (M–A) reaction of nucleoside H-phosphonate derivatives...

Descripción completa

Detalles Bibliográficos
Autores principales: Conlon, Patrick F., Eguaogie, Olga, Wilson, Jordan J., Sweet, Jamie S. T., Steinhoegl, Julian, Englert, Klaudia, Hancox, Oliver G. A., Law, Christopher J., Allman, Sarah A., Tucker, James H. R., Hall, James P., Vyle, Joseph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066676/
https://www.ncbi.nlm.nih.gov/pubmed/32190252
http://dx.doi.org/10.1039/c9sc04098f

Ejemplares similares

Ejemplares similares