Cargando…

Challenges and Opportunities to Updating Prescribing Information for Longstanding Oncology Drugs

A number of important drugs used to treat cancer—many of which serve as the backbone of modern chemotherapy regimens—have outdated prescribing information in their drug labeling. The Food and Drug Administration is undertaking a pilot project to develop a process and criteria for updating prescribin...

Descripción completa

Detalles Bibliográficos
Autores principales: Balogh, Erin P., Bindman, Andrew B., Eckhardt, S. Gail, Halabi, Susan, Harvey, R. Donald, Jaiyesimi, Ishmael, Miksad, Rebecca, Moses, Harold L., Nass, Sharyl J., Schilsky, Richard L., Sun, Steven, Torrente, Josephine M., Warren, Katherine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066705/
https://www.ncbi.nlm.nih.gov/pubmed/32162805
http://dx.doi.org/10.1634/theoncologist.2019-0698
Descripción
Sumario:A number of important drugs used to treat cancer—many of which serve as the backbone of modern chemotherapy regimens—have outdated prescribing information in their drug labeling. The Food and Drug Administration is undertaking a pilot project to develop a process and criteria for updating prescribing information for longstanding oncology drugs, based on the breadth of knowledge the cancer community has accumulated with the use of these drugs over time. This article highlights a number of considerations for labeling updates, including selecting priorities for updating; data sources and evidentiary criteria; as well as the risks, challenges, and opportunities for iterative review to ensure prescribing information for oncology drugs remains relevant to current clinical practice.