Highly-selective µ-opioid receptor antagonism does not block L-DOPA-induced dyskinesia in a rodent model

OBJECTIVES: Dopamine-replacement utilizing L-DOPA is still the mainstay treatment for Parkinson’s disease (PD), but often leads to development of L-DOPA-induced dyskinesia (LID), which can be as debilitating as the motor deficits. There is currently no satisfactory pharmacological adjunct therapy. T...

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Detalles Bibliográficos
Autores principales: Bartlett, Mitchell J., So, Lisa Y., Szabò, Lajos, Skinner, David P., Parent, Kate L., Heien, Michael L., Vanderah, Todd W., Polt, Robin, Sherman, Scott J., Falk, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066739/
https://www.ncbi.nlm.nih.gov/pubmed/32164786
http://dx.doi.org/10.1186/s13104-020-04994-7

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