Knocking-out the Siah2 E3 ubiquitin ligase prevents mitochondrial NCX3 degradation, regulates mitochondrial fission and fusion, and restores mitochondrial function in hypoxic neurons

BACKGROUND: Na(+)/Ca(2)(+) exchanger isoform 3 (NCX3) regulates mitochondrial Ca(2+) handling through the outer mitochondrial membrane (OMM) and promotes neuronal survival during oxygen and glucose deprivation (OGD). Conversely, Seven In-Absentia Homolog 2 (Siah2), an E3-ubiquitin ligase, which is a...

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Detalles Bibliográficos
Autores principales: Sisalli, Maria Josè, Ianniello, Gaetano, Savoia, Claudia, Cuomo, Ornella, Annunziato, Lucio, Scorziello, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066748/
https://www.ncbi.nlm.nih.gov/pubmed/32164721
http://dx.doi.org/10.1186/s12964-020-0529-x

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