Expression and function of cartilage-derived pluripotent cells in joint development and repair

Cartilage-derived pluripotent cells reside in hyaline cartilage and fibrocartilage. These cells have the potential for multidirectional differentiation; can undergo adipogenesis, osteogenesis, and chondrogenesis; and have been classified as mesenchymal stem cells (MSCs) conforming to the minimal cri...

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Detalles Bibliográficos
Autores principales: Jiang, Zhou, Yu, Sijing, Lin, Hengyi, Bi, Ruiye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066750/
https://www.ncbi.nlm.nih.gov/pubmed/32160923
http://dx.doi.org/10.1186/s13287-020-01604-y
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author Jiang, Zhou
Yu, Sijing
Lin, Hengyi
Bi, Ruiye
author_facet Jiang, Zhou
Yu, Sijing
Lin, Hengyi
Bi, Ruiye
author_sort Jiang, Zhou
collection PubMed
description Cartilage-derived pluripotent cells reside in hyaline cartilage and fibrocartilage. These cells have the potential for multidirectional differentiation; can undergo adipogenesis, osteogenesis, and chondrogenesis; and have been classified as mesenchymal stem cells (MSCs) conforming to the minimal criteria of the International Society for Cellular Therapy. Cartilage tissue is prone to injury and is difficult to repair. As cartilage-derived pluripotent cells are the closest cell source to cartilage tissue, they are expected to have the strongest ability to differentiate into cartilage compared to other MSCs. This review focuses on the organizational distribution, expression, and function of cartilage-derived pluripotent cells in joint development and repair to help explore the therapeutic potential of in situ cartilage-derived pluripotent cells for joint cartilage repair.
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spelling pubmed-70667502020-03-18 Expression and function of cartilage-derived pluripotent cells in joint development and repair Jiang, Zhou Yu, Sijing Lin, Hengyi Bi, Ruiye Stem Cell Res Ther Review Cartilage-derived pluripotent cells reside in hyaline cartilage and fibrocartilage. These cells have the potential for multidirectional differentiation; can undergo adipogenesis, osteogenesis, and chondrogenesis; and have been classified as mesenchymal stem cells (MSCs) conforming to the minimal criteria of the International Society for Cellular Therapy. Cartilage tissue is prone to injury and is difficult to repair. As cartilage-derived pluripotent cells are the closest cell source to cartilage tissue, they are expected to have the strongest ability to differentiate into cartilage compared to other MSCs. This review focuses on the organizational distribution, expression, and function of cartilage-derived pluripotent cells in joint development and repair to help explore the therapeutic potential of in situ cartilage-derived pluripotent cells for joint cartilage repair. BioMed Central 2020-03-12 /pmc/articles/PMC7066750/ /pubmed/32160923 http://dx.doi.org/10.1186/s13287-020-01604-y Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Jiang, Zhou
Yu, Sijing
Lin, Hengyi
Bi, Ruiye
Expression and function of cartilage-derived pluripotent cells in joint development and repair
title Expression and function of cartilage-derived pluripotent cells in joint development and repair
title_full Expression and function of cartilage-derived pluripotent cells in joint development and repair
title_fullStr Expression and function of cartilage-derived pluripotent cells in joint development and repair
title_full_unstemmed Expression and function of cartilage-derived pluripotent cells in joint development and repair
title_short Expression and function of cartilage-derived pluripotent cells in joint development and repair
title_sort expression and function of cartilage-derived pluripotent cells in joint development and repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066750/
https://www.ncbi.nlm.nih.gov/pubmed/32160923
http://dx.doi.org/10.1186/s13287-020-01604-y
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