Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites

INTRODUCTION: Metoprolol succinate is a long-acting beta-blocker prescribed for the management of hypertension (HTN) and other cardiovascular diseases. Metabolomics, the study of end-stage metabolites of upstream biologic processes, yield insight into mechanisms of drug effectiveness and safety. Our...

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Detalles Bibliográficos
Autores principales: Brocker, Chad N., Velenosi, Thomas, Flaten, Hania K., McWilliams, Glenn, McDaniel, Kyle, Shelton, Shelby K., Saben, Jessica, Krausz, Kristopher W., Gonzalez, Frank J., Monte, Andrew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066769/
https://www.ncbi.nlm.nih.gov/pubmed/32160915
http://dx.doi.org/10.1186/s40246-020-00260-w

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