The replisome guides nucleosome assembly during DNA replication

Nucleosome assembly during DNA replication is tightly coupled to ongoing DNA synthesis. This process, termed DNA replication-coupled (RC) nucleosome assembly, is essential for chromatin replication and has a great impact on both genome stability maintenance and epigenetic inheritance. This review di...

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Detalles Bibliográficos
Autores principales: Zhang, Wenshuo, Feng, Jianxun, Li, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066812/
https://www.ncbi.nlm.nih.gov/pubmed/32190287
http://dx.doi.org/10.1186/s13578-020-00398-z
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author Zhang, Wenshuo
Feng, Jianxun
Li, Qing
author_facet Zhang, Wenshuo
Feng, Jianxun
Li, Qing
author_sort Zhang, Wenshuo
collection PubMed
description Nucleosome assembly during DNA replication is tightly coupled to ongoing DNA synthesis. This process, termed DNA replication-coupled (RC) nucleosome assembly, is essential for chromatin replication and has a great impact on both genome stability maintenance and epigenetic inheritance. This review discusses a set of recent findings regarding the role of replisome components contributing to RC nucleosome assembly. Starting with a brief introduction to the factors involved in nucleosome assembly and some aspects of the architecture of the eukaryotic replisome, we discuss studies from yeast to mammalian cells and the interactions of replisome components with histones and histone chaperones. We describe the proposed functions of replisome components during RC nucleosome assembly and discuss their impacts on histone segregation and implications for epigenetic inheritance.
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spelling pubmed-70668122020-03-18 The replisome guides nucleosome assembly during DNA replication Zhang, Wenshuo Feng, Jianxun Li, Qing Cell Biosci Review Nucleosome assembly during DNA replication is tightly coupled to ongoing DNA synthesis. This process, termed DNA replication-coupled (RC) nucleosome assembly, is essential for chromatin replication and has a great impact on both genome stability maintenance and epigenetic inheritance. This review discusses a set of recent findings regarding the role of replisome components contributing to RC nucleosome assembly. Starting with a brief introduction to the factors involved in nucleosome assembly and some aspects of the architecture of the eukaryotic replisome, we discuss studies from yeast to mammalian cells and the interactions of replisome components with histones and histone chaperones. We describe the proposed functions of replisome components during RC nucleosome assembly and discuss their impacts on histone segregation and implications for epigenetic inheritance. BioMed Central 2020-03-12 /pmc/articles/PMC7066812/ /pubmed/32190287 http://dx.doi.org/10.1186/s13578-020-00398-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Wenshuo
Feng, Jianxun
Li, Qing
The replisome guides nucleosome assembly during DNA replication
title The replisome guides nucleosome assembly during DNA replication
title_full The replisome guides nucleosome assembly during DNA replication
title_fullStr The replisome guides nucleosome assembly during DNA replication
title_full_unstemmed The replisome guides nucleosome assembly during DNA replication
title_short The replisome guides nucleosome assembly during DNA replication
title_sort replisome guides nucleosome assembly during dna replication
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066812/
https://www.ncbi.nlm.nih.gov/pubmed/32190287
http://dx.doi.org/10.1186/s13578-020-00398-z
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