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Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity

A hypothesis that simultaneous targeting cancer-related carbonic anhydrase hCA IX and hCA XII isoforms (whose overexpression is a cancer cell’s defence mechanism against hypoxia) along with thioredoxin reductase (overexpressed in cancers as a defence against oxidative stress) may lead to synergistic...

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Detalles Bibliográficos
Autores principales:	Krasavin, Mikhail, Sharonova, Tatiana, Sharoyko, Vladimir, Zhukovsky, Daniil, Kalinin, Stanislav, Žalubovskis, Raivis, Tennikova, Tatiana, Supuran, Claudiu T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067156/ https://www.ncbi.nlm.nih.gov/pubmed/32131646 http://dx.doi.org/10.1080/14756366.2020.1734800

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