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Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees
Background: Psychological traumatic experiences can lead to posttraumatic stress disorder (PTSD). Secondary psychotic symptoms are not common but may occur. Objectives: Since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067194/ https://www.ncbi.nlm.nih.gov/pubmed/32194922 http://dx.doi.org/10.1080/20008198.2020.1730091 |
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author | Uldall, Sigurd Wiingaard Nielsen, Mette Ødegaard Carlsson, Jessica Glenthøj, Birte Siebner, Hartwig Roman Madsen, Kristoffer Hougaard Madsen, Camilla Gøbel Leffers, Anne-Mette Nejad, Ayna Baladi Rostrup, Egill |
author_facet | Uldall, Sigurd Wiingaard Nielsen, Mette Ødegaard Carlsson, Jessica Glenthøj, Birte Siebner, Hartwig Roman Madsen, Kristoffer Hougaard Madsen, Camilla Gøbel Leffers, Anne-Mette Nejad, Ayna Baladi Rostrup, Egill |
author_sort | Uldall, Sigurd Wiingaard |
collection | PubMed |
description | Background: Psychological traumatic experiences can lead to posttraumatic stress disorder (PTSD). Secondary psychotic symptoms are not common but may occur. Objectives: Since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm we investigate whether the same finding extends to psychotic and anhedonic symptoms in PTSD. Methods: A total of 70 male refugees: 18 PTSD patients with no secondary psychotic symptoms (PTSD-NSP), 21 PTSD patients with secondary psychotic symptoms (PTSD-SP), and 31 healthy controls (RHC) were interviewed and scanned with functional magnetic resonance imaging (fMRI) during a monetary incentive delay task. Using region of interest analysis of the prefrontal cortex and ventral striatum, we investigated reward-related activity. Results: Compared to RHC, participants with PTSD had decreased neural activity during monetary reward. Also, participants with PTSD-SP exhibited decreased activity in the associative striatum relative to participants with PTSD-NSP during processing of motivational reward anticipation which correlated with severity of psychotic symptoms. However, the difference between the two PTSD groups disappeared when PTSD severity and trauma exposure were accounted for. Conclusions: Anhedonia and secondary psychotic symptoms in PTSD are characterized by dysfunctional reward consumption and anticipation processing, respectively. The latter may reflect a mechanism by which abnormal reward signals in the basal ganglia facilitates psychotic symptoms across psychiatric conditions. |
format | Online Article Text |
id | pubmed-7067194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-70671942020-03-19 Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees Uldall, Sigurd Wiingaard Nielsen, Mette Ødegaard Carlsson, Jessica Glenthøj, Birte Siebner, Hartwig Roman Madsen, Kristoffer Hougaard Madsen, Camilla Gøbel Leffers, Anne-Mette Nejad, Ayna Baladi Rostrup, Egill Eur J Psychotraumatol Basic Research Article Background: Psychological traumatic experiences can lead to posttraumatic stress disorder (PTSD). Secondary psychotic symptoms are not common but may occur. Objectives: Since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm we investigate whether the same finding extends to psychotic and anhedonic symptoms in PTSD. Methods: A total of 70 male refugees: 18 PTSD patients with no secondary psychotic symptoms (PTSD-NSP), 21 PTSD patients with secondary psychotic symptoms (PTSD-SP), and 31 healthy controls (RHC) were interviewed and scanned with functional magnetic resonance imaging (fMRI) during a monetary incentive delay task. Using region of interest analysis of the prefrontal cortex and ventral striatum, we investigated reward-related activity. Results: Compared to RHC, participants with PTSD had decreased neural activity during monetary reward. Also, participants with PTSD-SP exhibited decreased activity in the associative striatum relative to participants with PTSD-NSP during processing of motivational reward anticipation which correlated with severity of psychotic symptoms. However, the difference between the two PTSD groups disappeared when PTSD severity and trauma exposure were accounted for. Conclusions: Anhedonia and secondary psychotic symptoms in PTSD are characterized by dysfunctional reward consumption and anticipation processing, respectively. The latter may reflect a mechanism by which abnormal reward signals in the basal ganglia facilitates psychotic symptoms across psychiatric conditions. Taylor & Francis 2020-03-04 /pmc/articles/PMC7067194/ /pubmed/32194922 http://dx.doi.org/10.1080/20008198.2020.1730091 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Basic Research Article Uldall, Sigurd Wiingaard Nielsen, Mette Ødegaard Carlsson, Jessica Glenthøj, Birte Siebner, Hartwig Roman Madsen, Kristoffer Hougaard Madsen, Camilla Gøbel Leffers, Anne-Mette Nejad, Ayna Baladi Rostrup, Egill Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees |
title | Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees |
title_full | Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees |
title_fullStr | Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees |
title_full_unstemmed | Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees |
title_short | Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees |
title_sort | associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees |
topic | Basic Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067194/ https://www.ncbi.nlm.nih.gov/pubmed/32194922 http://dx.doi.org/10.1080/20008198.2020.1730091 |
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