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Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees

Background: Psychological traumatic experiences can lead to posttraumatic stress disorder (PTSD). Secondary psychotic symptoms are not common but may occur. Objectives: Since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm...

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Autores principales: Uldall, Sigurd Wiingaard, Nielsen, Mette Ødegaard, Carlsson, Jessica, Glenthøj, Birte, Siebner, Hartwig Roman, Madsen, Kristoffer Hougaard, Madsen, Camilla Gøbel, Leffers, Anne-Mette, Nejad, Ayna Baladi, Rostrup, Egill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067194/
https://www.ncbi.nlm.nih.gov/pubmed/32194922
http://dx.doi.org/10.1080/20008198.2020.1730091
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author Uldall, Sigurd Wiingaard
Nielsen, Mette Ødegaard
Carlsson, Jessica
Glenthøj, Birte
Siebner, Hartwig Roman
Madsen, Kristoffer Hougaard
Madsen, Camilla Gøbel
Leffers, Anne-Mette
Nejad, Ayna Baladi
Rostrup, Egill
author_facet Uldall, Sigurd Wiingaard
Nielsen, Mette Ødegaard
Carlsson, Jessica
Glenthøj, Birte
Siebner, Hartwig Roman
Madsen, Kristoffer Hougaard
Madsen, Camilla Gøbel
Leffers, Anne-Mette
Nejad, Ayna Baladi
Rostrup, Egill
author_sort Uldall, Sigurd Wiingaard
collection PubMed
description Background: Psychological traumatic experiences can lead to posttraumatic stress disorder (PTSD). Secondary psychotic symptoms are not common but may occur. Objectives: Since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm we investigate whether the same finding extends to psychotic and anhedonic symptoms in PTSD. Methods: A total of 70 male refugees: 18 PTSD patients with no secondary psychotic symptoms (PTSD-NSP), 21 PTSD patients with secondary psychotic symptoms (PTSD-SP), and 31 healthy controls (RHC) were interviewed and scanned with functional magnetic resonance imaging (fMRI) during a monetary incentive delay task. Using region of interest analysis of the prefrontal cortex and ventral striatum, we investigated reward-related activity. Results: Compared to RHC, participants with PTSD had decreased neural activity during monetary reward. Also, participants with PTSD-SP exhibited decreased activity in the associative striatum relative to participants with PTSD-NSP during processing of motivational reward anticipation which correlated with severity of psychotic symptoms. However, the difference between the two PTSD groups disappeared when PTSD severity and trauma exposure were accounted for. Conclusions: Anhedonia and secondary psychotic symptoms in PTSD are characterized by dysfunctional reward consumption and anticipation processing, respectively. The latter may reflect a mechanism by which abnormal reward signals in the basal ganglia facilitates psychotic symptoms across psychiatric conditions.
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spelling pubmed-70671942020-03-19 Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees Uldall, Sigurd Wiingaard Nielsen, Mette Ødegaard Carlsson, Jessica Glenthøj, Birte Siebner, Hartwig Roman Madsen, Kristoffer Hougaard Madsen, Camilla Gøbel Leffers, Anne-Mette Nejad, Ayna Baladi Rostrup, Egill Eur J Psychotraumatol Basic Research Article Background: Psychological traumatic experiences can lead to posttraumatic stress disorder (PTSD). Secondary psychotic symptoms are not common but may occur. Objectives: Since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm we investigate whether the same finding extends to psychotic and anhedonic symptoms in PTSD. Methods: A total of 70 male refugees: 18 PTSD patients with no secondary psychotic symptoms (PTSD-NSP), 21 PTSD patients with secondary psychotic symptoms (PTSD-SP), and 31 healthy controls (RHC) were interviewed and scanned with functional magnetic resonance imaging (fMRI) during a monetary incentive delay task. Using region of interest analysis of the prefrontal cortex and ventral striatum, we investigated reward-related activity. Results: Compared to RHC, participants with PTSD had decreased neural activity during monetary reward. Also, participants with PTSD-SP exhibited decreased activity in the associative striatum relative to participants with PTSD-NSP during processing of motivational reward anticipation which correlated with severity of psychotic symptoms. However, the difference between the two PTSD groups disappeared when PTSD severity and trauma exposure were accounted for. Conclusions: Anhedonia and secondary psychotic symptoms in PTSD are characterized by dysfunctional reward consumption and anticipation processing, respectively. The latter may reflect a mechanism by which abnormal reward signals in the basal ganglia facilitates psychotic symptoms across psychiatric conditions. Taylor & Francis 2020-03-04 /pmc/articles/PMC7067194/ /pubmed/32194922 http://dx.doi.org/10.1080/20008198.2020.1730091 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic Research Article
Uldall, Sigurd Wiingaard
Nielsen, Mette Ødegaard
Carlsson, Jessica
Glenthøj, Birte
Siebner, Hartwig Roman
Madsen, Kristoffer Hougaard
Madsen, Camilla Gøbel
Leffers, Anne-Mette
Nejad, Ayna Baladi
Rostrup, Egill
Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees
title Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees
title_full Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees
title_fullStr Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees
title_full_unstemmed Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees
title_short Associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees
title_sort associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees
topic Basic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067194/
https://www.ncbi.nlm.nih.gov/pubmed/32194922
http://dx.doi.org/10.1080/20008198.2020.1730091
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