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Biosynthesis of plant tetrahydroisoquinoline alkaloids through an imine reductase route

Herein, we report a biocatalytic approach to synthesize plant tetrahydroisoquinoline alkaloids (THIQAs) from dihydroisoquinoline (DHIQ) precursors using imine reductases and N-methyltransferase (NMT). The imine reductase IR45 was engineered to significantly expand its substrate specificity, enabling...

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Detalles Bibliográficos
Autores principales:	Yang, Lu, Zhu, Jinmei, Sun, Chenghai, Deng, Zixin, Qu, Xudong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067268/ https://www.ncbi.nlm.nih.gov/pubmed/32190259 http://dx.doi.org/10.1039/c9sc03773j

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