Three-dimensional brain-on-chip model using human iPSC-derived GABAergic neurons and astrocytes: Butyrylcholinesterase post-treatment for acute malathion exposure

Organophosphates (OPs) induce acute and chronic neurotoxicity, primarily by inhibiting acetylcholinesterase (AChE) activity as well as by necrosis, and apoptosis. Butyrylcholinesterase (BuChE), an exogenous bioscavenger of OPs, can be used as a treatment for OP exposure. It is prerequisite to develo...

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Detalles Bibliográficos
Autores principales: Liu, Lumei, Koo, Youngmi, Russell, Teal, Gay, Elaine, Li, Yan, Yun, Yeoheung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067464/
https://www.ncbi.nlm.nih.gov/pubmed/32163499
http://dx.doi.org/10.1371/journal.pone.0230335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067464/
https://www.ncbi.nlm.nih.gov/pubmed/32163499
http://dx.doi.org/10.1371/journal.pone.0230335

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