Polarized lung inflammation and Tie2/angiopoietin-mediated endothelial dysfunction during severe Orientia tsutsugamushi infection

Orientia tsutsugamushi infection can cause acute lung injury and high mortality in humans; however, the underlying mechanisms are unclear. Here, we tested a hypothesis that dysregulated pulmonary inflammation and Tie2-mediated endothelial malfunction contribute to lung damage. Using a murine model o...

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Detalles Bibliográficos
Autores principales: Trent, Brandon, Liang, Yuejin, Xing, Yan, Esqueda, Marisol, Wei, Yang, Cho, Nam-Hyuk, Kim, Hong-Il, Kim, Yeon-Sook, Shelite, Thomas R., Cai, Jiyang, Sun, Jiaren, Bouyer, Donald H., Liu, Jinjun, Soong, Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067486/
https://www.ncbi.nlm.nih.gov/pubmed/32119672
http://dx.doi.org/10.1371/journal.pntd.0007675

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