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Asymmetric sampling in human auditory cortex reveals spectral processing hierarchy

Speech perception is mediated by both left and right auditory cortices but with differential sensitivity to specific acoustic information contained in the speech signal. A detailed description of this functional asymmetry is missing, and the underlying models are widely debated. We analyzed cortical...

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Autores principales: Giroud, Jérémy, Trébuchon, Agnès, Schön, Daniele, Marquis, Patrick, Liegeois-Chauvel, Catherine, Poeppel, David, Morillon, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067489/
https://www.ncbi.nlm.nih.gov/pubmed/32119667
http://dx.doi.org/10.1371/journal.pbio.3000207
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author Giroud, Jérémy
Trébuchon, Agnès
Schön, Daniele
Marquis, Patrick
Liegeois-Chauvel, Catherine
Poeppel, David
Morillon, Benjamin
author_facet Giroud, Jérémy
Trébuchon, Agnès
Schön, Daniele
Marquis, Patrick
Liegeois-Chauvel, Catherine
Poeppel, David
Morillon, Benjamin
author_sort Giroud, Jérémy
collection PubMed
description Speech perception is mediated by both left and right auditory cortices but with differential sensitivity to specific acoustic information contained in the speech signal. A detailed description of this functional asymmetry is missing, and the underlying models are widely debated. We analyzed cortical responses from 96 epilepsy patients with electrode implantation in left or right primary, secondary, and/or association auditory cortex (AAC). We presented short acoustic transients to noninvasively estimate the dynamical properties of multiple functional regions along the auditory cortical hierarchy. We show remarkably similar bimodal spectral response profiles in left and right primary and secondary regions, with evoked activity composed of dynamics in the theta (around 4–8 Hz) and beta–gamma (around 15–40 Hz) ranges. Beyond these first cortical levels of auditory processing, a hemispheric asymmetry emerged, with delta and beta band (3/15 Hz) responsivity prevailing in the right hemisphere and theta and gamma band (6/40 Hz) activity prevailing in the left. This asymmetry is also present during syllables presentation, but the evoked responses in AAC are more heterogeneous, with the co-occurrence of alpha (around 10 Hz) and gamma (>25 Hz) activity bilaterally. These intracranial data provide a more fine-grained and nuanced characterization of cortical auditory processing in the 2 hemispheres, shedding light on the neural dynamics that potentially shape auditory and speech processing at different levels of the cortical hierarchy.
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spelling pubmed-70674892020-03-23 Asymmetric sampling in human auditory cortex reveals spectral processing hierarchy Giroud, Jérémy Trébuchon, Agnès Schön, Daniele Marquis, Patrick Liegeois-Chauvel, Catherine Poeppel, David Morillon, Benjamin PLoS Biol Research Article Speech perception is mediated by both left and right auditory cortices but with differential sensitivity to specific acoustic information contained in the speech signal. A detailed description of this functional asymmetry is missing, and the underlying models are widely debated. We analyzed cortical responses from 96 epilepsy patients with electrode implantation in left or right primary, secondary, and/or association auditory cortex (AAC). We presented short acoustic transients to noninvasively estimate the dynamical properties of multiple functional regions along the auditory cortical hierarchy. We show remarkably similar bimodal spectral response profiles in left and right primary and secondary regions, with evoked activity composed of dynamics in the theta (around 4–8 Hz) and beta–gamma (around 15–40 Hz) ranges. Beyond these first cortical levels of auditory processing, a hemispheric asymmetry emerged, with delta and beta band (3/15 Hz) responsivity prevailing in the right hemisphere and theta and gamma band (6/40 Hz) activity prevailing in the left. This asymmetry is also present during syllables presentation, but the evoked responses in AAC are more heterogeneous, with the co-occurrence of alpha (around 10 Hz) and gamma (>25 Hz) activity bilaterally. These intracranial data provide a more fine-grained and nuanced characterization of cortical auditory processing in the 2 hemispheres, shedding light on the neural dynamics that potentially shape auditory and speech processing at different levels of the cortical hierarchy. Public Library of Science 2020-03-02 /pmc/articles/PMC7067489/ /pubmed/32119667 http://dx.doi.org/10.1371/journal.pbio.3000207 Text en © 2020 Giroud et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Giroud, Jérémy
Trébuchon, Agnès
Schön, Daniele
Marquis, Patrick
Liegeois-Chauvel, Catherine
Poeppel, David
Morillon, Benjamin
Asymmetric sampling in human auditory cortex reveals spectral processing hierarchy
title Asymmetric sampling in human auditory cortex reveals spectral processing hierarchy
title_full Asymmetric sampling in human auditory cortex reveals spectral processing hierarchy
title_fullStr Asymmetric sampling in human auditory cortex reveals spectral processing hierarchy
title_full_unstemmed Asymmetric sampling in human auditory cortex reveals spectral processing hierarchy
title_short Asymmetric sampling in human auditory cortex reveals spectral processing hierarchy
title_sort asymmetric sampling in human auditory cortex reveals spectral processing hierarchy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067489/
https://www.ncbi.nlm.nih.gov/pubmed/32119667
http://dx.doi.org/10.1371/journal.pbio.3000207
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