Variable prediction accuracy of polygenic scores within an ancestry group

Fields as diverse as human genetics and sociology are increasingly using polygenic scores based on genome-wide association studies (GWAS) for phenotypic prediction. However, recent work has shown that polygenic scores have limited portability across groups of different genetic ancestries, restrictin...

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Detalles Bibliográficos
Autores principales: Mostafavi, Hakhamanesh, Harpak, Arbel, Agarwal, Ipsita, Conley, Dalton, Pritchard, Jonathan K, Przeworski, Molly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067566/
https://www.ncbi.nlm.nih.gov/pubmed/31999256
http://dx.doi.org/10.7554/eLife.48376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067566/
https://www.ncbi.nlm.nih.gov/pubmed/31999256
http://dx.doi.org/10.7554/eLife.48376

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