Cargando…

IL-2/IL-2 Receptor Pathway Plays a Crucial Role in the Growth and Malignant Transformation of HTLV-1-Infected T Cells to Develop Adult T-Cell Leukemia

T cells infected with human T-cell leukemia virus type 1 (HTLV-1) transform into malignant/leukemic cells and develop adult T-cell leukemia (ATL) after a long latency period. The tax (transactivator from the X-gene region) and HBZ (HTLV-1 bZIP factor) genes of HTLV-1 play crucial roles in the develo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maeda, Michiyuki, Tanabe-Shibuya, Junko, Miyazato, Paola, Masutani, Hiroshi, Yasunaga, Jun-ichirou, Usami, Kazumasa, Shimizu, Akira, Matsuoka, Masao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067701/ https://www.ncbi.nlm.nih.gov/pubmed/32210945 http://dx.doi.org/10.3389/fmicb.2020.00356

Ejemplares similares

Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells
por: Mahgoub, Mohamed, et al.
Publicado: (2018)

Molecular mechanisms of apoptosis suppression by HTLV-1 bZIP factor in HTLV-1 infected cells
por: Tanaka-Nakanishi, Azusa, et al.
Publicado: (2014)

Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis
por: Ma, Guangyong, et al.
Publicado: (2016)

STLV-1-infected Japanese macaque as a model of HTLV-1 infection
por: Miura, Michi, et al.
Publicado: (2014)

HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors
por: Kinosada, Haruka, et al.
Publicado: (2017)

Correction: HTLV-1 bZIP Factor Enhances T-cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors
por: Kinosada, Haruka, et al.
Publicado: (2017)

HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo
por: Satou, Yorifumi, et al.
Publicado: (2011)

ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells
por: Hagiya, Keita, et al.
Publicado: (2011)

Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice
por: Mitagami, Yu, et al.
Publicado: (2015)

Correction: Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice
por: Mitagami, Yu, et al.
Publicado: (2015)

Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms
por: Taniguchi, Yuko, et al.
Publicado: (2005)

HTLV-1 bZIP factor perturbs immune response to the pathogens in vivo by inhibiting IFN-gamma production
por: Sugata, Kenji, et al.
Publicado: (2011)

Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection
por: Miura, Michi, et al.
Publicado: (2013)

HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling
por: Higuchi, Yusuke, et al.
Publicado: (2020)

In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
por: Saito, Mineki, et al.
Publicado: (2009)

APH-2 and Tax expression are correlated with a HTLV-2 proviral load but not with lymphocytosis
por: Douceron, Estelle, et al.
Publicado: (2011)

IL-6 Plays a Crucial Role in HBV Infection
por: Lan, Tian, et al.
Publicado: (2015)

Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP
por: Naito, Tadasuke, et al.
Publicado: (2018)

HTLV-1 bZIP factor-mediated dysfunction of regulatory T cells in vivo
por: Miyazato, Paola, et al.
Publicado: (2011)

HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT)
por: Yasuma, Keiko, et al.
Publicado: (2016)

HTLV-1 bZIP factor suppresses c-Fos transcription and impairs T cell activation
por: Kawatsuki, Akihiro, et al.
Publicado: (2014)

A Critical Role for IL-17RB Signaling in HTLV-1 Tax-Induced NF-κB Activation and T-Cell Transformation
por: Lavorgna, Alfonso, et al.
Publicado: (2014)

A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation
por: Lavorgna, Alfonso, et al.
Publicado: (2015)

HTLV-1 modulates the frequency and phenotype of FoxP3(+)CD4(+) T cells in virus-infected individuals
por: Satou, Yorifumi, et al.
Publicado: (2012)

Oncogenic spiral by infectious pathogens: Cooperation of multiple factors in cancer development
por: Yasunaga, Jun‐Ichirou, et al.
Publicado: (2017)

HTLV-1-mediated dysregulation of the Wnt pathways: roles of Tax and HBZ
por: Ma, Guangyong, et al.
Publicado: (2014)

Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody
por: Sugata, Kenji, et al.
Publicado: (2016)

In vivo dynamics and adaptation of HTLV-1-infected clones under different clinical conditions
por: Izaki, Mikiko, et al.
Publicado: (2021)

HTLV-1 Alters T Cells for Viral Persistence and Transmission
por: Tanaka, Azusa, et al.
Publicado: (2018)

HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia
por: Takiuchi, Yoko, et al.
Publicado: (2017)

HTLV-1 bZIP Factor Induces Inflammation through Labile Foxp3 Expression
por: Yamamoto-Taguchi, Nanae, et al.
Publicado: (2013)

Anti-CCR4 antibody activates virus specific immune response in STLV-1 infected Japanese monkey
por: Sugata, Kenji, et al.
Publicado: (2015)

Necroptosis Plays a Crucial Role in Vascular Injury during DVT and Is Enhanced by IL-17B
por: Li, Yunyan, et al.
Publicado: (2022)

M-Sec induced by HTLV-1 mediates an efficient viral transmission
por: Hiyoshi, Masateru, et al.
Publicado: (2021)

HBZ and its roles in HTLV-1 oncogenesis
por: Zhao, Tiejun, et al.
Publicado: (2012)

Systematic clustering algorithm for chromatin accessibility data and its application to hematopoietic cells
por: Tanaka, Azusa, et al.
Publicado: (2020)

Pseudo-progression of adult T-cell leukemia-lymphoma after cord blood transplantation
por: Fuji, Shigeo, et al.
Publicado: (2022)

153 Molecular pathogenesis by HTLV-1 bZIP factor
por: Matsuoka, Masao
Publicado: (2014)

Macrophages as IL-25/IL-33-Responsive Cells Play an Important Role in the Induction of Type 2 Immunity
por: Yang, Zhonghan, et al.
Publicado: (2013)

Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation
por: Chen, Z, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_aj9dcels4tuahojctbtuivu503