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Gastrin, Cholecystokinin, Signaling, and Biological Activities in Cellular Processes

The structurally-related peptides, gastrin and cholecystokinin (CCK), were originally discovered as humoral stimulants of gastric acid secretion and pancreatic enzyme release, respectively. With the aid of methodological advances in biochemistry, immunochemistry, and molecular biology in the past se...

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Detalles Bibliográficos
Autores principales: Zeng, Qiang, Ou, Lei, Wang, Wei, Guo, Dong-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067705/
https://www.ncbi.nlm.nih.gov/pubmed/32210918
http://dx.doi.org/10.3389/fendo.2020.00112
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author Zeng, Qiang
Ou, Lei
Wang, Wei
Guo, Dong-Yu
author_facet Zeng, Qiang
Ou, Lei
Wang, Wei
Guo, Dong-Yu
author_sort Zeng, Qiang
collection PubMed
description The structurally-related peptides, gastrin and cholecystokinin (CCK), were originally discovered as humoral stimulants of gastric acid secretion and pancreatic enzyme release, respectively. With the aid of methodological advances in biochemistry, immunochemistry, and molecular biology in the past several decades, our concept of gastrin and CCK as simple gastrointestinal hormones has changed considerably. Extensive in vitro and in vivo studies have shown that gastrin and CCK play important roles in several cellular processes including maintenance of gastric mucosa and pancreatic islet integrity, neurogenesis, and neoplastic transformation. Indeed, gastrin and CCK, as well as their receptors, are expressed in a variety of tumor cell lines, animal models, and human samples, and might contribute to certain carcinogenesis. In this review, we will briefly introduce the gastrin and CCK system and highlight the effects of gastrin and CCK in the regulation of cell proliferation and apoptosis in both normal and abnormal conditions. The potential imaging and therapeutic use of these peptides and their derivatives are also summarized.
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spelling pubmed-70677052020-03-24 Gastrin, Cholecystokinin, Signaling, and Biological Activities in Cellular Processes Zeng, Qiang Ou, Lei Wang, Wei Guo, Dong-Yu Front Endocrinol (Lausanne) Endocrinology The structurally-related peptides, gastrin and cholecystokinin (CCK), were originally discovered as humoral stimulants of gastric acid secretion and pancreatic enzyme release, respectively. With the aid of methodological advances in biochemistry, immunochemistry, and molecular biology in the past several decades, our concept of gastrin and CCK as simple gastrointestinal hormones has changed considerably. Extensive in vitro and in vivo studies have shown that gastrin and CCK play important roles in several cellular processes including maintenance of gastric mucosa and pancreatic islet integrity, neurogenesis, and neoplastic transformation. Indeed, gastrin and CCK, as well as their receptors, are expressed in a variety of tumor cell lines, animal models, and human samples, and might contribute to certain carcinogenesis. In this review, we will briefly introduce the gastrin and CCK system and highlight the effects of gastrin and CCK in the regulation of cell proliferation and apoptosis in both normal and abnormal conditions. The potential imaging and therapeutic use of these peptides and their derivatives are also summarized. Frontiers Media S.A. 2020-03-06 /pmc/articles/PMC7067705/ /pubmed/32210918 http://dx.doi.org/10.3389/fendo.2020.00112 Text en Copyright © 2020 Zeng, Ou, Wang and Guo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zeng, Qiang
Ou, Lei
Wang, Wei
Guo, Dong-Yu
Gastrin, Cholecystokinin, Signaling, and Biological Activities in Cellular Processes
title Gastrin, Cholecystokinin, Signaling, and Biological Activities in Cellular Processes
title_full Gastrin, Cholecystokinin, Signaling, and Biological Activities in Cellular Processes
title_fullStr Gastrin, Cholecystokinin, Signaling, and Biological Activities in Cellular Processes
title_full_unstemmed Gastrin, Cholecystokinin, Signaling, and Biological Activities in Cellular Processes
title_short Gastrin, Cholecystokinin, Signaling, and Biological Activities in Cellular Processes
title_sort gastrin, cholecystokinin, signaling, and biological activities in cellular processes
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067705/
https://www.ncbi.nlm.nih.gov/pubmed/32210918
http://dx.doi.org/10.3389/fendo.2020.00112
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