Complexities in Genetics of Psoriatic Arthritis

PURPOSE OF THE REVIEW: To provide a general overview and current challenges regarding the genetics of psoriatic disease. With the use of integrative medicine, multiple candidate loci identified to date in psoriatic disease will be annotated, summarized, and visualized. Recent studies reporting diffe...

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Autores principales: Rahmati, Sara, Tsoi, Lam, O’Rielly, Darren, Chandran, Vinod, Rahman, Proton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Psoriatic Arthritis (J Scher, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067725/
https://www.ncbi.nlm.nih.gov/pubmed/32166449
http://dx.doi.org/10.1007/s11926-020-0886-x
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author Rahmati, Sara
Tsoi, Lam
O’Rielly, Darren
Chandran, Vinod
Rahman, Proton
author_facet Rahmati, Sara
Tsoi, Lam
O’Rielly, Darren
Chandran, Vinod
Rahman, Proton
author_sort Rahmati, Sara
collection PubMed
description PURPOSE OF THE REVIEW: To provide a general overview and current challenges regarding the genetics of psoriatic disease. With the use of integrative medicine, multiple candidate loci identified to date in psoriatic disease will be annotated, summarized, and visualized. Recent studies reporting differences in genetic architecture between psoriatic arthritis and cutaneous-only psoriasis will be highlighted. RECENT FINDINGS: Focusing on functional pathways that connect previously identified genetic variants can increase our understanding of psoriatic diseases. The genetic architecture differs between psoriatic arthritis and cutaneous-only psoriasis with arthritis-specific signals in linkage disequilibrium independent of the published psoriasis signals. SUMMARY: Integrative medicine is helpful in understanding cellular mechanisms of psoriatic diseases. Careful selection of the psoriatic disease cohort has translated into mechanistic differences among psoriatic arthritis and cutaneous psoriasis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11926-020-0886-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-70677252020-03-23 Complexities in Genetics of Psoriatic Arthritis Rahmati, Sara Tsoi, Lam O’Rielly, Darren Chandran, Vinod Rahman, Proton Curr Rheumatol Rep Psoriatic Arthritis (J Scher, Section Editor) PURPOSE OF THE REVIEW: To provide a general overview and current challenges regarding the genetics of psoriatic disease. With the use of integrative medicine, multiple candidate loci identified to date in psoriatic disease will be annotated, summarized, and visualized. Recent studies reporting differences in genetic architecture between psoriatic arthritis and cutaneous-only psoriasis will be highlighted. RECENT FINDINGS: Focusing on functional pathways that connect previously identified genetic variants can increase our understanding of psoriatic diseases. The genetic architecture differs between psoriatic arthritis and cutaneous-only psoriasis with arthritis-specific signals in linkage disequilibrium independent of the published psoriasis signals. SUMMARY: Integrative medicine is helpful in understanding cellular mechanisms of psoriatic diseases. Careful selection of the psoriatic disease cohort has translated into mechanistic differences among psoriatic arthritis and cutaneous psoriasis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11926-020-0886-x) contains supplementary material, which is available to authorized users. Springer US 2020-03-12 2020 /pmc/articles/PMC7067725/ /pubmed/32166449 http://dx.doi.org/10.1007/s11926-020-0886-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Psoriatic Arthritis (J Scher, Section Editor)
Rahmati, Sara
Tsoi, Lam
O’Rielly, Darren
Chandran, Vinod
Rahman, Proton
Complexities in Genetics of Psoriatic Arthritis
title Complexities in Genetics of Psoriatic Arthritis
title_full Complexities in Genetics of Psoriatic Arthritis
title_fullStr Complexities in Genetics of Psoriatic Arthritis
title_full_unstemmed Complexities in Genetics of Psoriatic Arthritis
title_short Complexities in Genetics of Psoriatic Arthritis
title_sort complexities in genetics of psoriatic arthritis
topic Psoriatic Arthritis (J Scher, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067725/
https://www.ncbi.nlm.nih.gov/pubmed/32166449
http://dx.doi.org/10.1007/s11926-020-0886-x
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