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Synchrotron radiation imaging analysis of neural damage in mouse soleus muscle
Damage to lower limb muscles requires accurate analysis of the muscular condition via objective microscopic diagnosis. However, microscopic tissue analysis may cause deformation of the tissue structure due to injury induced by external factors during tissue sectioning. To substantiate these muscle i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067770/ https://www.ncbi.nlm.nih.gov/pubmed/32165699 http://dx.doi.org/10.1038/s41598-020-61599-7 |
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author | Lee, Jiwon Jang, Sang-Hun Lee, Suk-Jun Lee, Onseok |
author_facet | Lee, Jiwon Jang, Sang-Hun Lee, Suk-Jun Lee, Onseok |
author_sort | Lee, Jiwon |
collection | PubMed |
description | Damage to lower limb muscles requires accurate analysis of the muscular condition via objective microscopic diagnosis. However, microscopic tissue analysis may cause deformation of the tissue structure due to injury induced by external factors during tissue sectioning. To substantiate these muscle injuries, we used synchrotron X-ray imaging technology to project extremely small objects, provide three-dimensional microstructural analysis as extracted samples. In this study, we used mice as experimental animals to create soleus muscle models with various nerve injuries. We morphologically analyzed and quantified the damaged Section and Crush muscles, respectively, via three-dimensional visualization using synchrotron radiation X-ray imaging to diagnose muscle injury. Results of this study can also be used as basic data in the medical imaging field. |
format | Online Article Text |
id | pubmed-7067770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70677702020-03-19 Synchrotron radiation imaging analysis of neural damage in mouse soleus muscle Lee, Jiwon Jang, Sang-Hun Lee, Suk-Jun Lee, Onseok Sci Rep Article Damage to lower limb muscles requires accurate analysis of the muscular condition via objective microscopic diagnosis. However, microscopic tissue analysis may cause deformation of the tissue structure due to injury induced by external factors during tissue sectioning. To substantiate these muscle injuries, we used synchrotron X-ray imaging technology to project extremely small objects, provide three-dimensional microstructural analysis as extracted samples. In this study, we used mice as experimental animals to create soleus muscle models with various nerve injuries. We morphologically analyzed and quantified the damaged Section and Crush muscles, respectively, via three-dimensional visualization using synchrotron radiation X-ray imaging to diagnose muscle injury. Results of this study can also be used as basic data in the medical imaging field. Nature Publishing Group UK 2020-03-12 /pmc/articles/PMC7067770/ /pubmed/32165699 http://dx.doi.org/10.1038/s41598-020-61599-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lee, Jiwon Jang, Sang-Hun Lee, Suk-Jun Lee, Onseok Synchrotron radiation imaging analysis of neural damage in mouse soleus muscle |
title | Synchrotron radiation imaging analysis of neural damage in mouse soleus muscle |
title_full | Synchrotron radiation imaging analysis of neural damage in mouse soleus muscle |
title_fullStr | Synchrotron radiation imaging analysis of neural damage in mouse soleus muscle |
title_full_unstemmed | Synchrotron radiation imaging analysis of neural damage in mouse soleus muscle |
title_short | Synchrotron radiation imaging analysis of neural damage in mouse soleus muscle |
title_sort | synchrotron radiation imaging analysis of neural damage in mouse soleus muscle |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067770/ https://www.ncbi.nlm.nih.gov/pubmed/32165699 http://dx.doi.org/10.1038/s41598-020-61599-7 |
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